ABSTRACT
Introduction ............................................................................................................ 150 Reaction Procedure ................................................................................................ 151
General Procedure for the Suzuki Cross-Coupling Reaction ............................ 151 Conventional Procedure .................................................................................... 151
Notes ...................................................................................................................... 152 Ethyl 7-Hydroxy-2-Oxo-2H-Chromene-3-Carboxylate .................................... 154 Ethyl 7-Hydroxy-8-Iodo-2-Oxo-2H-Chromene-3-Carboxylate (4) .................. 155 (E)-3-(Benzo[d][1,3]Dioxol-5-yl)-1-(Biphenyl-4-yl)Prop-2-en-1-One (2a) .... 155 (E)-3-(Benzo[d][1,3]Dioxol-5-yl)-1-(4′-Methoxybiphenyl-4-yl)Prop-2-en1-One (2b) ......................................................................................................... 155 (E)-3-(Benzo[d][1,3]Dioxol-5-yl)-1-(3′-Nitrobiphenyl-4-yl)Prop-2-en-1One (2c) ............................................................................................................. 156 (E)-3-(Benzo[d][1,3]Dioxol-5-yl)-1-(3′-Methoxybiphenyl-4-yl)Prop-2-en1-One (2d) ......................................................................................................... 156 (E)-3-(Benzo[d][1,3]Dioxol-5-yl)-1-(3′-Fluoro-4′-Methoxybiphenyl-4-yl) Prop-2-en-1-One (2e) ........................................................................................ 156 (E)-3-(Benzo[d][1,3]Dioxol-5-yl)-1-(4′-Fluoro-3′-Methylbiphenyl-4-yl) Prop-2-en-1-One (2f) ........................................................................................ 156 (E)-3-(Benzo[d][1,3]Dioxol-5-yl)-1-(4-(Benzo[d][1,3]Dioxol-5-yl)Phenyl) Prop-2-en-1-One (2g) ........................................................................................ 157 (E)-1-(Benzo[d][1,3]Dioxol-5-yl)-3-(Biphenyl-4-yl)Prop-2-en-1-One (2h) .... 157
Chalcones and coumarins are important naturally occurring plant constituents and display a wide range of pharmacological and biological activities.1,2 From a synthetic perspective, chalcone and coumarin derivatives are gaining more prominence due to their pivotal role in organic synthesis.3 However, only a few methods have been already reported for the derivatization of this class of compounds under Suzuki cross-coupling conditions.4
