ABSTRACT
In inverse or parameter estimation problems as discussed in Chapter 2, an important but practical question is how successful the mathematical model is in describing the physical or biological phenomena represented by the experimental data. In general, it is very unlikely that the residual sum of squares (RSS) in the inverse least squares formulation is zero. Indeed, due to modeling error, there may not even be a true set of parameters so that the mathematical model will provide an exact fit to the experimental data.
