ABSTRACT
Pretreatment of vascular smooth muscle cells with berberine inhibited platelet-derived growth factor-induced proliferation. Berberine significantly suppressed platelet-derived growth factor F-stimulated cyclin D1/D3 and cyclin-dependent kinase gene expression. Moreover, berberine increased the activity of AMP-activated protein kinase, which led to phosphorylation activation of p53* and increased protein levels of the Cdk inhibitor p21**.
