ABSTRACT
This chapter describes a wide variety of chemicals that disrupt arthropod blood feeding. The exact mechanism of action of these compounds is still uncertain, but they all have the net effect of stopping bites. Many chemicals discovered so far give the hope that there is a compound that is far more effective than current active ingredients. At this time, ve compounds are in common use, though there are others with a smaller market share (e.g., 2-undecanone1). The ve compounds include one that was derived botanically (para-menthane-3,8-diol [PMD]), two developed through molecular modeling (picaridin and IR3535®*), one discovered by screening many possible compounds (deet), and one derived from a similar chemical structure (N,N-diethyl phenylacetamide [DEPA]). This chapter reviews the basic properties and effectiveness of these ve compounds.
