ABSTRACT

Since the publication of the landmark work of Barker et al. [1], the potential for early life exposures to impact on later disease risk has captured the imagination of researchers. In this early work, low birth weight was associated with increased risk for ischemic heart disease in later life. Since then, very elegant studies of the Overkalix parish in Northern Sweden have demonstrated that nutrition during key periods of development of both parents is associated with mortality, heart disease, and diabetes in children and even grandchildren [2-4].