ABSTRACT
Meglitinides have similar mechanisms of action (MoA). ◾ Biguanides: ↓ Hepatic production and ↓ peripheral utilization of glucose, metfor-
min (Glucophage®); phenformin withdrawn 1976, 2° fatal lactic acidosis 2° inhibition gluconeogenesis.
Meglitinides have similar mechanisms of action (MoA). ◾ Biguanides: ↓ Hepatic production and ↓ peripheral utilization of glucose, metfor-
min (Glucophage®); phenformin withdrawn 1976, 2° fatal lactic acidosis 2° inhibition gluconeogenesis.