Hypoglycemic and Other Endocrine Agent Toxicity

Meglitinides have similar mechanisms of action (MoA). ◾ Biguanides: ↓ Hepatic production and ↓ peripheral utilization of glucose, metfor-

min (Glucophage®); phenformin withdrawn 1976, 2° fatal lactic acidosis 2° inhibition gluconeogenesis.