ABSTRACT
Specific Mx MTX OD (See Figure 14.2) ◾ Antidote: Leucovorin (folinic acid)—restores reduced folate; monitor with ↓ MTX
levels. Folic acid ineffective; not in active form. ◾ Enhanced elimination: Hemoperfusion best: HP > HP + HD > HD (removes both
folic and folinic acids). ◾ Granulocyte colony-stimulating factor (G-CSF): For ↓ BM and pancytopenia.
