ABSTRACT
Metal oxide nanoparticles exhibit unique properties that largely differ from those displayed by their larger counterparts. These properties are highly desirable, rendering these nanomaterials very useful for many different types of applications such as consumer products like cosmetics or textiles and also paints or fuel additives. An
8.1 Introduction .................................................................................................. 159 8.2 Effects of Metal Oxide Nanoparticles on Cultured Cells ............................. 161
8.2.1 Oxidative Stress ................................................................................ 163 8.2.2 Cell Viability .................................................................................... 167 8.2.3 Genotoxicity...................................................................................... 168 8.2.4 Gene Expression Proles .................................................................. 171 8.2.5 Inammatory Response .................................................................... 171
8.3 Effects of Metal Oxide Nanoparticles on Primary Alveolar Macrophages .....172 8.4 Effects of Metal Oxide Nanoparticles in Animals ....................................... 173
8.4.1 Biological Activity of Metal Oxide Nanoparticles in Rat Lungs after Intratracheal Instillation ........................................................... 173
8.4.2 Biological Activity of Metal Oxide Nanoparticles in Rat Lungs after Inhalation ................................................................................. 174
8.4.3 Effects of Metal Oxide Nanoparticles on Animals with Allergic Airway Inammation ....................................................................... 178
8.5 Case Study on Correlations of In Vivo and In Vitro Data ............................ 180 8.6 Summary and Conclusion ............................................................................. 182 References .............................................................................................................. 184
overview of nanomaterial containing consumer products in the US declared by the manufacturer is available at the Wilson Center Project on Emerging Nanotechnologies Consumer Products Inventory (https://www.nanotechproject.org/cpi).
