ABSTRACT
Trade names: Letairis (Gilead), Volibris (GSK) Indications: Pulmonary arterial hypertension Class: Antihypertensive, Endothelin receptor (ETR) antagonist, Vasodilator Half-life: 9 hours Clinically important, potentially hazardous interactions with: conivaptan, cyclosporine, CYP2C19 inhibitors and inducers, CYP3A4 inhibitors and inducers, dasatinib, deferasirox, grapefruit juice, St John’s wort Pregnancy category: X Note: Contraindicated in pregnancy and in patients with idiopathic pulmonary fibrosis.
