ABSTRACT
Trade names: Elavil (AstraZeneca), Limbitrol (Valeant) Indications: Depression Class: Antidepressant, tricyclic, Muscarinic antagonist Half-life: 10-25 hours Clinically important, potentially hazardous interactions with: adrenergic neurone blockers, alcohol, alfuzosin, altretamine, amiodarone, amphetamines, amprenavir, anticholinergics, antiepileptics, antihistamines, antimuscarinics, antipsychotics, apraclonidine, arsenic, artemether / lumefantrine, aspirin, atomoxetine, baclofen, barbiturates, brimonidine, bupropion, cannabis extract, carbamazepine, cimetidine, cinacalcet, ciprofloxacin, cisapride, clonidine, clozapine, conivaptan, coumarins, CYP2D6 inhibitors, desmopressin, dexmethylphenidate, diltiazem, disopyramide, disulfiram, diuretics, dronedarone, droperidol, duloxetine, elvitegravir / cobicistat / emtricitabine / tenofovir, entacapone, ephedra, epinephrine, estrogens, eucalyptus, flecainide, gadobutrol, general anesthetics, gotu kola, grapefruit juice, guanethidine, histamine, interferon alfa, iobenguane, isocarboxazid, isoproterenol, kava, linezolid, lithium, MAO inhibitors, methylphenidate, metoclopramide, moclobemide, moxifloxacin, moxonidine, nefopam, nicorandil, nilotinib, nitrates, NSAIDs, opioid analgesics, paroxetine, pentamidine, phenelzine, phenothiazines, phenytoin, pimozide, pramlintide, primidone, propafenone, propoxyphene, protease inhibitors, QT interval prolonging agents, quinidine, quinine, quinolones, rasagiline, ritonavir, saquinavir, selegiline, sibutramine, sodium oxybate, sotalol, sparfloxacin, SSRIs, St John’s wort, sulfonylureas, terbinafine, tetrabenazine, thioridazine, thyroid hormones, tramadol, tranylcypromine, valerian, valproic acid, verapamil, vitamin K antagonists, yohimbine, ziprasidone Pregnancy category: C Note: Not recommended for pediatric patients <12 years of age. Limbitrol is amitriptyline and chlordiazepoxide.
