ABSTRACT
Trade names: Epitol (Teva), Tegretol (Novartis) Indications: Epilepsy, pain or trigeminal neuralgia Class: Anticonvulsant, Antipsychotic, CYP1A2 inducer, CYP3A4 inducer, Mood stabilizer Half-life: 18-55 hours Clinically important, potentially hazardous interactions with: abiraterone, acetaminophen, acetylcysteine, adenosine, afatinib, amitriptyline, amlodipine, amprenavir, apixaban, apremilast, aprepitant, aripiprazole, artemether / lumefantrine, boceprevir, buprenorphine, cabazitaxel, cabozantinib, caffeine, caspofungin, cefixime, charcoal, citalopram, clarithromycin, clobazam, clopidogrel, clorazepate, clozapine, crizotinib, dabigatran, darunavir, dasatinib, delavirdine, dexamethasone, diltiazem, doxacurium, doxycycline, dronedarone, efavirenz, elvitegravir / cobicistat / emtricitabine / tenofovir, enzalutamide, erythromycin, eslicarbazepine, estradiol, ethosuximide, etravirine, ezogabine, felodipine, fesoterodine, fosamprenavir, gefitinib, imatinib, indinavir, influenza vaccine, isotretinoin, itraconazole, ixabepilone, lacosamide, lapatinib, levetiracetam, levomepromazine, levonorgestrel, linezolid, lopinavir, methylprednisolone, midazolam, mifepristone, nelfinavir, nevirapine, nifedipine, nilotinib, olanzapine, ondansetron, oxcarbazepine, oxtriphylline, paclitaxel, paliperidone, perampanel, piracetam, ponatinib, prednisolone, propoxyphene, regorafenib, rilpivirine, riociguat, risperidone, ritonavir, rivaroxaban, roflumilast, romidepsin, rufinamide, simeprevir, simvastatin, sodium picosulfate, sofosbuvir, solifenacin, sorafenib, St John’s wort, sunitinib, telaprevir, telithromycin, temsirolimus, terbinafine, thalidomide, tiagabine, ticagrelor, tipranavir, tolvaptan, tramadol, triamcinolone, troleandomycin, ulipristal, vandetanib, vemurafenib, verapamil, voriconazole, vortioxetine, ziprasidone, zuclopenthixol Pregnancy category: D Note: Carbamazepine is the main cause of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and the hypersensitivity syndrome in Han Chinese, and in peoples of other Southeast Asian countries, as a result of a strong pharmacogenetic association that has been reported in these patients between the human leukocyte antigen (HLA)-B*1502 and carbamazepine.
