ABSTRACT
HYDROCHLOROTHIAZIDE Trade names: Accuretic (Pfizer), Aldactazide (Pfizer), Aldoril (Merck), Atacand HCT (AstraZeneca), Avalide (Bristol-Myers Squibb), Capozide (Par), Diovan HCT (Novartis), Dyazide (GSK), Hyzaar (Merck), Inderide (Wyeth), Lopressor (Novartis), Lotensin (Novartis), Lotensin HCT (Novartis), Micardis (Boehringer Ingelheim), Microzide (Watson), Moduretic (Merck), Prinzide (Merck), Tekturna HCT (Novartis), Teveten HCT (Biovail), Uniretic (Schwarz), Vaseretic (Biovail), Zestoretic (AstraZeneca), Ziac (Barr) Indications: Edema Class: Diuretic, thiazide Half-life: 5.6-14.8 hours Clinically important, potentially hazardous interactions with: digoxin, dofetilide, lithium, zinc Pregnancy category: B Note: Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome. Hydrochlorothiazide is often used in combination, e.g. with aliskiren (Tekturna HCT); amiloride (Moduretic); benazepril (Lotensin HCT); bisoprolol (Ziac); captopril (Capozide); enalapril (Vaseretic); irbesartan (Avalide); lisinopril (Prinzide and Zestoretic); losartan (Hyzaar); methyldopa (Aldoril); moexipril (Uniretic); spironolactone (Aldactazide); triamterene (Dyazide and Maxzide).
