ABSTRACT
Anti-emetics are a diverse group of agents with a variety of modes of action. Once the cause of the vomiting is known, the most logical anti-emetic is chosen, taking into account the cause for the vomiting. Antihistamines act on receptors both in the gastrointestinal tract and on the vestibular nucleus. As such, they are particularly effective in the treatment of emesis resulting from gastrointestinal pathology or problems with the inner ear/vestibular apparatus. Potential side effects of cyclizine include sedation and tachycardia. Other drugs junior doctors may occasionally come across for the management of nausea and vomiting include: Dexamethasone; Haloperidol; and Nabilone. The Medicines and Healthcare Products Regulatory Agency has released new guidelines that metoclopramide and domperidone should only be used for the shortest durations possible due to adverse effects.
