ABSTRACT
Systems biology approaches have become indispensable in processing huge and heterogeneous biomedical data, extracting essential information and forming novel hypotheses from various experimental results. In the field of neurotrauma studies, decades of efforts in animal experiments and clinical studies accumulated wealthy knowledge on the pathophysiology of traumatic brain injury (TBI). Application of systems biology strategies to holistically analyze the complex molecular pathways and networks of brain trauma can be of high importance due to its impact on biomarker research. In this chapter, we discuss current available systems biology strategies, databases, and tools and their applications to existing TBI data sets that can be used to identify new biomarker candidates investigating the different underlying molecular mechanisms and pathways of TBI responses.
