The goal of this chapter is to describe four relatively noninvasive rehabilitative paradigms that may have clinical relevance following brain injury. Specifically, the benefits and limitations of environmental enrichment, exercise, low-level laser therapy, and constraint-induced movement therapy will be discussed. Timing issues (e.g., best time to initiate treatment as well as duration of treatment) and the advantage of adjunct therapies (i.e., can they further improve functional outcome) will also be discussed. Overall, the literature suggests that each of the aforementioned therapies confer significant behavioral improvement after experimental brain trauma. Hence, we propose that they should be considered for implementation in clinical rehabilitation.