ABSTRACT
It has become evident that protein-protein interactions play a central role in signal transduction, and are thus key regulators of cell function. It has also become clear that the identication of therapeutically important protein-protein interactions from among the thousands of contenders requires rapid and robust screening
CONTENTS
7.1 Introduction .................................................................................................. 181 7.2 Extracellular Protein-Protein Interactions ................................................... 182
7.2.1 Erythropoietin Receptor ................................................................... 183 7.2.2 Insulin-Like Growth Factor .............................................................. 184 7.2.3 Vascular Endothelial Growth Factor ................................................ 186 7.2.4 Immunoglobulin G ........................................................................... 187 7.2.5 Factor VII ......................................................................................... 189 7.2.6 Summary of Extracellular Protein-Protein Interactions .................. 190
7.3 Intracellular Protein-Protein Interactions .................................................... 191 7.3.1 PDZ Domains ................................................................................... 191 7.3.2 Inhibitors of Apoptosis ..................................................................... 193
7.4 Structured Libraries and Small Proteins ...................................................... 195 7.5 Bicycles-Chemically Tethered Peptide Loops ........................................... 195 7.6 Small Proteins-Libraries Based on the Z-Domain Scaffold ...................... 197 7.7 Scaffold Libraries against D-Proteins .......................................................... 199 7.8 Conclusions ...................................................................................................200 References ..............................................................................................................200
