ABSTRACT
Discovery for Nuclear Receptors .......................................268 10.4 Summary ......................................................................................................269 References .............................................................................................................. 270
10.1 INTRODUCTION
Phage-displayed peptide libraries can be used to isolate specic, high-afnity peptides to almost any protein target. Peptides have been identied for a wide range of protein targets including antibodies [1,2], enzymes [3,4], G proteins [5], nuclear receptors [6,7], cytokine receptors [8,9], cytokines [10], transcription factors [11], and protein interaction domains [12-14]. The peptides identied by afnity selection from phage-displayed peptide libraries bind to biologically relevant sites on these target proteins and therefore can serve as valuable reagents for dissecting the biological function of proteins as well as tools for drug discovery.
