This chapter aims to understand the main threats to Western companies, operating both domestically and internationally. It outlines how geopolitics, terrorism, cyber issues, espionage, single-issue activism, and crime affect the safe and security operations of companies and organizations both domestically and on the global stage. The security operating environment of the twenty-first century presents a wide range of challenges to organizations. In business environment, corporations of all sizes need to concern themselves ever more with the threat posed by political events outside their control. Developments have provided a stark reminder to organizations that political risks can affect their activities, objectives, and profitability. Single-issue activism and political violence can have considerable effects on an organization’s reputation, its employees, and its continuity, regardless of whether it is the target or has been collaterally affected by some other action. The range of potential threats facing a company can be overwhelming, and their impact can be high.