Once a facility is constructed, risk managers have several tools to mitigate biorisks identified in the risk assessment. They can decide to eliminate the risk or substitute it; they can use equipment to mitigate risks, such as biosafety cabinets, badge readers, or personal protective equipment (PPE); they can decide who will have access and execute the work; and they can change work practices and administrative controls. Although these are all elements that should be considered at the time of design of a facility, they are also the same tools available to adjust the mitigations as needed to accommodate changes in mission. Risk managers must understand the various options that can be used to mitigate risks because no matter how well planned a facility is, the mission will inevitably evolve and risk mitigations will need to be reevaluated.