A biorisk management system functions to control risks associated with handling, storage, and disposal of biological agents and toxins. The AMP (assessment, mitigation, and performance) model for biorisk management requires that control measures (mitigation) be based on a substantive risk assessment (assessment) and also that the effectiveness and suitability of the control measures be evaluated (performance). Although performance is generally evaluated after mitigation is implemented, designing appropriate performance indicators must be part of the planning process. Common strategies used currently to measure performance often rely on failure data and may benefit by utilizing additional indicators that measure more proactive activities and outcomes. Using the results from performance measurement is imperative to make effective changes or improvements to the system, and a continually improving system is a hallmark of an effective biorisk management program.