ABSTRACT
Response-adaptive randomization or allocation is a randomization technique
in which the allocation of patients to treatment groups is based on the re-
sponses (outcomes) of the previous patients. The main purpose is to provide
a better chance of randomizing the patients to a superior treatment group
based on the knowledge about the treatment effect at the time of randomiza-
tion. As a result, response-adaptive randomization takes ethical concerns into
consideration. In the response-adaptive randomization, the response have not
to be on the primary endpoint of the trial; instead, the randomization can be
based on the response of a biomarker.