ABSTRACT

Inefciency in drug delivery has been a serious problem in drug development for years. It signicantly compromises the drug action at the target site/tissue, while it simultaneously increases the damage to normal tissue, causing serious adverse events in patients. Furthermore, diagnostic and monitoring capacity has been hampered by inefcient reagent delivery. One approach in addressing these problems has been to subject drug molecules and delivery vectors to chemical and biological modications by applying nanotechnology [1]. This includes the employment of varied nanomaterials including synthetic materials and naturally occurring biomaterials [2]. In this context, various liposomeand polymer-based formulations have been engineered for drugs such as Doxil® [3] and triptorelin [4], respectively.