ABSTRACT
De‹ned Animal Model ..................................................................................................................992 Renal Impairment, Xenobiotic Metabolism, and Toxicity ........................................................993 Hepatic Impairment: Xenobiotic Metabolism and Toxicity ......................................................997 Impaired GI Absorption .......................................................................................................... 1002 Pregnancy ................................................................................................................................1004 Inœuence of Gender on Xenobiotic Absorption, Disposition, and Toxicity ............................1007 Microbiological De‹nition ...................................................................................................... 1015 Genetic De‹nition (Genomics).................................................................................................1016
Environmental and Nutritional Condition ................................................................................... 1020 Susceptibility Factors ................................................................................................................... 1020 Summary ...................................................................................................................................... 1021
