ABSTRACT
Theuse of animals in experimental medicine, pharmacology, pharmaceutical and medical device development, safety assessment, and toxicological evaluation is awell-established, regulatorilyrequired, and essential practice. Whether serving as asource of isolated organelles, cells, or tissues,adisease model, or apredictive model for drug or other xenobiotic action or transformation in man, animal models have provided the necessary building blocks that have permitted the explosive growth of medical and biological knowledge in the later half of the twentieth century and into the
CONTENTS
Background ........................................................................................................................................1 Current Animal Studies .....................................................................................................................2 Origins of Predictive Animal Testing ................................................................................................3
