ABSTRACT
The Magnesium (Mg) alloy implant exhibited a faster degradation within the bone tissue or areas with high blood supply, that is, the marrow cavity or the cancellous bone, than within the cortical bone tissue. The subcutaneous gas cavities were clinically observed in approximately 30% of the reported cases for bare Mg alloy tests, which usually initiated in the early stage of implantation and gradually disappeared without special treatment with moderate inflammatory response. Most studies published on Mg implants report beneficial osteoinductive effects of Mg alloys. The first clinical trial to test the feasibility and safety of the Mg bioabsorbable stent was performed in 20 patients with critical limb ischemia (CLI). The absorbable metallic stents (AMS) INSIGHT is a prospective, multicenter, randomized study, designed to evaluate the safety and performance of the first-generation AMS for the treatment of infrapopliteal lesions in patients with CLI.
