In addition, large differences exist in life expectancy between different species, and this offers a unique paradigm to investigate the genetic architecture of longevity in natural conditions.

6.2 NOTHOBRANCHIUS: A HISTORICAL PERSPECTIVE

Nothobranchius annual shes experienced an initial moment of interest in the 1970s and 1980s. N. guentheri was rst studied in the context of sexual selection by Haas (2006) and were then used in some exploratory aging studies but never became established, possibly due to the relatively long lifespan of this species, which is about 18 months (Bailey, 1972; Markofsky and Perlmutter, 1973; Markofsky, 1976; Markofsky and Milstoc, 1979; Balmer, 1982; Cooper et al., 1983). Several species of Nothobranchius were studied during the same period as a model system for embryological studies,

CONTENTS

6.1 Introduction ............................................................................................................................93 6.2 Nothobranchius: A Historical Perspective .............................................................................93 6.3 Nothobranchius as a Model in Developmental Biology .........................................................94 6.4 Nothobranchius Furzeri as an Aging Model ..........................................................................94 6.5 Genome-Wide Gene Expression Studies on Aging ................................................................95 6.6 Nothobranchius as a Model for Quantitative Genetics ..........................................................95 6.7 Nothobranchius as an Experimental Model: Nongenetic Interventions ................................95 6.8 Nothobranchius as an Experimental Model: Genetic Interventions ......................................96 6.9 Nothobranchius: Future Perspectives .....................................................................................96 References ........................................................................................................................................96