ABSTRACT
Previously discussed misconceptions in QSAR are not the only misconceptions oating around in several research circles of QSAR. From time to time one hears cries, particularly from those who are in QSAR using exclusively physicochemical properties as molecular descriptors, that there are enough topological indices. First, they should be the least concerned with this issue, because (i) they are neither using topological indices, (ii) nor are they familiar with topological indices. They apparently lament that there are enough studies of indices and that researchers in mathematical chemistry should awake and start solving “real world” problems! Well, it is amusing that those who are, with respect to research in mathematical chemistry, “sleeping” should call others to awaken! Such “criticism” reminds us of an old anonymous saying: “People with the least expertise have the most opinions.” These criticisms reect more on those who raise objections than on those being criticized.
