ABSTRACT
Minerals are critical for the optimal function of the human body. These nutrients are responsible for many basic roles including uid balance, enzyme activity, and protein synthesis. Their absence or inadequacy has been found to promote disease states across anatomic systems. A substantial body of research has linked mineral deciencies to poor brain development, cognitive decits, and a diversity of psychiatric symptoms. Specically, it is well-established that several key minerals are necessary to support neurotransmitter systems. This chapter will focus on the inuence of individual mineral deciencies, including those of zinc, magnesium, and lithium, on the pathophysiology of depression. Consequently, trials demonstrating their efcacy as mono-and adjunctive antidepressant therapies will also be presented. From this collection of evidence it is clear that maintaining adequate levels of specic minerals is important for modulating depressive symptoms. Furthermore, the mechanisms through which each mineral act are unique and varied, making targeted assessment and supplementation crucial for successful outcomes.
