ABSTRACT
The World Health Organization (WHO) states that overweight and obesity are the fth leading risk for global deaths (James 2008). At least 2.8 million adults die each year as a result of being overweight or obese. The metabolic syndrome (MetS) is a cluster of obesity-related metabolic derangements such as insulin resistance, hypertension, hyperglycemia, and dyslipidemia, which predispose the development of type 2 diabetes, cardiovascular disease (CVD), and mortality (Reaven 2008). Subjects with MetS have three times risk of suffering a heart attack or stroke, twice of dying from such an event, and vefold greater risk of developing type 2 diabetes when compared to normal subjects (Stern et al. 2004). Beyond these factors, many other path physiologic features have been identied in patients with MetS, such as chronic systemic inammation, which has its origin in the
3.1 Introduction ............................................................................................................................ 33 3.2 Obesity and Inammation ......................................................................................................34
