ABSTRACT

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Quan Wen University of Electronic Science and Technology of China Chengdu, People’s Republic of China

Hitoshi Iyatomi Hosei University Tokyo, Japan

Kouhei Shimizu Hosei University Tokyo, Japan

Huiyu Zhou Queen’s University Belfast Belfast, United Kingdom

Gerald Schaefer Loughborough University Loughborough, United Kingdom

CONTENTS 4.1 Introduction .........................................................................................98 4.2 Preprocessing ..................................................................................... 100

4.2.1 Color Space Transformation ................................................... 100 4.2.2 Contrast Enhancement ........................................................... 101 4.2.3 Approximate Lesion Localization ........................................... 101 4.2.4 Artifact Removal .................................................................... 102

4.3 Segmentation...................................................................................... 104 4.4 Postprocessing.................................................................................... 105

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4.5 Evaluation .......................................................................................... 106 4.6 Comparisons and Discussion .............................................................. 109 Acknowledgments ...................................................................................... 114 References .................................................................................................. 114

4.1 INTRODUCTION Invasive and in situ malignant melanoma together comprise one of the most rapidly increasing cancers in the world. Invasive melanoma alone has an estimated incidence of 73,870 and an estimated total of 9940 deaths in the United States in 2015 [1]. Early diagnosis is particularly important since melanoma can be cured with a simple excision if detected early.