ABSTRACT
The total blood volume of the rhesus monkey (n = 23) derived by dilution of T-1824 dye and determination of the hematocrit by centrifugation in a Wintrobe tube was calculated to be 75.1 ± 12 mL/kg of the body weight (Overman and Feldman 1947). In another assessment also utilizing Evans blue dye (T-1824) coupled with 32P-labeled-erythrocytes dilution, the ratio of the volume of blood to the unit weight of the rhesus monkey was determined to be a mean 54.0 mL/kg (n = 18, 6-9 monthsold subjects) (Gregersen et al. 1959). Growth and increase of body weight monitored for more than 1 year (n = 2) did not alter the ratio. The quantitation of the blood volumes using 51Cr-labeled erythrocytes in one control and four anemic vitamin Edecient rhesus monkeys yielded values of 55 and 57 mL/kg, respectively (Fitch et al. 1980). The blood volume of the rhesus monkey (n = 10♂ and 10♀, prepubertal subjects, 2.2-5.3 kg) derived by the dilution of radioactive iodinated human serum albumin following a 10-minute postintravenous injection equilibration was determined to be a mean 60.9 mL/kg (Bender 1955). The probable error was estimated to be 1 mL/kg. The value of 61 mL/kg has been utilized or cited by Krise and Wald (1959), Bourne (1975), and Mandell and George (1991). In their investigation of the normal distribution of the cardiac output in the rhesus monkey, Forsyth et al. (1968) calculated the circulating blood volume to be 89.5 mL/kg (n = 6). The concept that the blood volume of the individual is in the range of 6% of one’s weight appears to be applicable to both the monkey and man.
