ABSTRACT
Tablet testing can be broadly divided into three aspects or categories: Confirmation of the nature of the active ingredient and the product; establishing pharmaceutical availability of the active moiety both in vitro and in vivo in humans and also in animals; and establishing stability profiles to achieve shelf life. This chapter provides an overview of the techniques used for this purpose and discussion of the generally accepted standards. The first and foremost important test in tablet testing is to establish that the tablets contain the labeled active ingredient. The uniformity of dosage units test is conducted to establish consistency in the content of active ingredient from tablet to tablet. Friability test is intended to determine, under defined conditions, the friability of uncoated tablets, the phenomenon whereby tablet surfaces are damaged and show evidence of breakage when subjected to mechanical shock or attrition. A disintegration test is a test to establish how fast a tablet disintegrates into aggregates and/or finer particles.
