ABSTRACT
Zeta-potential measurement has long been recognized as an excellent tool for characterizing colloidal systems. An empirical relationship was developed between the zeta potential and the coagulation behavior of a variety of systems. Zeta potential has also found an application in relating the surface-charge characteristics of a suspension to properties other than physical stability. The study of the effect of drug-loading on the zeta potential of liposomes provides information regarding the drug-liposome interaction. The measurement of the zeta potential of liposomes provides valuable information relating to their in vivo performance because, in addition to size, the surface charge of liposomes is an important determinant of their clearance from the general circulation and their tissue disposition after parenteral administration. The expanding role of zeta potential in these fields is attributable to the advance in modern instrumentation of zeta potential measurement, the rapid development of colloidal drug-delivery systems, and the emphasis on interdisciplinary basic research.
