ABSTRACT
ABSTRACT: The success of scaffolds for clinical applications is strictly related to the validation of key features such as biocompatibility, degradability, mechanical integrity, and bioactivity. For these reasons, the material design to replace lost structures, or to improve existing structures by the promotion of new tissue formation, moves toward the choice of materials, which show a wide survey of physical and chemical properties able to satisfy the heterogeneous demand in tissue engineering and regenerative medicine. In this chapter, a review of main strategies used to fabricate polymer-based composite and hybrid scaffolds in regenerative medicine is reported. The state of the art of porous scaffold and process technique are illustrated in the rst paragraph. Composite scaffolds are introduced in two subsections dealing with degradation properties of matrices and bioactivity of calcium phosphate llers. Finally, the second section is referred to synthesis approaches based on the assembly hybrid materials as scaffolds, empathizing the use of solgel reaction for the fabrication of porous nanocomposites.
