As the type species of the Leporipoxvirus genus in the Chordopoxvirinae subfamily, Poxviridae family, myxoma virus (MYXV) is a large, double-stranded DNA virus that replicates in the cytoplasm of infected cells. MYXV causes the generalized, frequently lethal disease, myxomatosis, in European rabbits (Oryctolagus cuniculus). Other leporipoxviruses include hare broma virus, rabbit broma virus (also called Shope’s broma virus), and squirrel broma virus, which naturally infect various leporid and squirrel species.