Bovine coronavirus (BCoV) is a single-stranded, positivesense RNA virus implicated in three distinct clinical syndromes in cattle: (1) calf diarrhea (CD), (2) winter dysentery (WD) with hemorrhagic diarrhea in adults, and (3) bovine respiratory disease complex (BRDC) or shipping fever of feedlot cattle. Given its common occurrence in dairy and beef cattle farms worldwide and its negative impact on milk production in dairy herds and weight gain in calves and adult cattle, considerable efforts have been made in recent years toward the elucidation of BCoV’s genetic characteristics, epidemiology, transmission, clinical features, pathogenesis, diagnosis, treatment, and prevention.