The blue eye disease, affecting pigs of all ages, is caused by a virus of the Rubulavirus genus, Paramyxoviridae family . The rst cases were reported in 1980, in hog farms at La Piedad, Michoacán, Mexico. Clinical signs, mostly of nervous nature, were observed in piglets younger than 30 days. New outbursts were reported later on the same year in the nearby states of Jalisco and Guanajuato and in 1983 in Mexico City, Nuevo León, Hidalgo, Tlaxcala, Tamaulipas, Puebla, Campeche, and Querétaro. Since its emergence, the disease has been difcult to control, and by 1992, it had spread to 16 states in Mexico . According to a seroprevalence survey of porcine rubulavirus (PRV) performed in 2004, a prevalence of 10%–30% was found in 18 Mexican states .