ABSTRACT
This chapter describes the use of capillary electromigration (CE) techniques for the study of liposomes and interactions between liposomes and compounds. Various CE techniques will be discussed and focus will be on the use of capillary (zone) electrophoresis for the investigation of physicochemical properties of liposomes. In addition, emphasis will be on the use of capillary electrokinetic chromatography (EKC), partial-filling EKC (PF-EKC), and capillary electrophoresis frontal analysis (CE-FA) as affinity electrophoretic modes for the study of liposome-analyte interactions. Finally, there will be discussion on how liposomes can be employed as either a shielding coating or as a stationary chromatographic phase in fused silica capillaries for CE. The latter technique is commonly called open-tubular capillary electrochromatography (OT-CEC). The use of CE for studying complexes between lipids or liposomes and analytes is also briefly discussed. Some practical applications, are given and the advantages and disadvantages of the different approaches are highlighted.
