ABSTRACT
Various types of formulations, both aqueous and non-aqueous, have been placed under the rubric of ‘‘liquid oral preparations,’’ including solutions, suspensions, and emulsions. As with other oral dosage forms, liquid oral preparations cannot be administered to the unconscious patient. Rubino has described various mechanisms and equations that were derived with the objective of establishing a basic understanding of and developing a mathematical approach for interpreting and predicting drug solubility behavior. The types and concentrations of sweeteners for common prescription liquid medications are reported by Hill, Flaitz, and Frost. Sucrose is the most widely used sweetener, with a long history of use. Furthermore, Monoammonium glycyrrhizinate has even been used in liquid oral preparations. Preservatives Liquid oral preparations are the most likely of all non-sterile pharmaceutical products to be contaminated by microorganisms. Methods of Preparation Dilute solutions of rapidly dissolving materials are prepared by adding solute to the solvent and agitating until the solution in homogeneous..
