ABSTRACT
Definition The mucosal surface of the penis extends from the preputial orifice to the urethral meatus and comprises the three penile epithelial compartments: foreskin inner surface, coronal sulcus, and glans.1,2
The vast majority of penile cancers are squamous cell carcinoma (SCC) arising in the squamous epithelium of one of these anatomic compartments.1,2 Primary cancers of the outer penile skin are extremely rare. We have identified only three cases after the examination of more than 1000 penectomy specimens with cancer. Distal urethral tumors are also unusual and in general discussed with urothelial cancers. Penile sarcomas and lymphomas are exceptional.2
