ABSTRACT
Figure 8.1). It is unclear how amyloid induces
tau phosphorylation; it is possible that tau
aggregation could precede phosphorylation
and it is conceivable (and fiercely argued) that
amyloid itself may result in cognitive
impairment and/or neuronal loss. However,
despite these unresolved matters the scheme
shown in figure 8.1 illustrates all of the
obvious disease-modification strategies that
have arisen out of the molecular biology of
AD.