Supportive Therapy Pain control is of paramount importance and often requires narcotic drugs and sometimes radiotherapy. Fractures may be present and require surgical fixation at times. Over the past 15 years, specialists have been increasingly using drugs belonging to the bisphosphonate family. Bisphosphonates are drugs which bind to the surface of damaged bones in patients with myeloma and other cancers, and by doing so are able to prevent bone destruction and help in the repair process of bone lesions. They have been found very useful both in the treatment of myeloma-related bone disease and also in controlling bone pain.