ABSTRACT
Physicians frequently evaluate indices of organ function as an endpoint of therapy. In the angina patient, relief of pain and resolution of ischemic electrocardiographic changes are viewed as success of antianginal therapy. Similarly, in renal disease, maintenance of adequate urine output, a normal creatinine and blood urea nitrogen (BUN) are useful global physiologic measures of renal health. Normal organ function implies at a minimum adequate blood flow and oxygen (O2) delivery.
