Experimental Mouse Model of Pemphigus Vulgaris: Passive Transfer of Nondesmoglein 1 and 3 Antibodies

I. History and Rationale ........................................................................................................286 A. Keratinocyte Antigens Targeted by Pemphigus Vulgaris Antibodies Are Not

Limited to Desmoglein 1 and 3 ................................................................................286 B. Acantholysis Induced by Pathogenic PV Autoantibodies May Be Mediated

Through Intracellular Signal Transduction ...............................................................288 1. Phosphorylation as a Result of Signal Transduction Induced by Binding

of PVIgG to KC Antigens ...................................................................................289 2. Activation of KC Protease as a Result of Cell Signaling Induced by

Binding of PVIgG to KC Antigens.....................................................................290 C. From Clinical Findings to the Concept and from the Concept to the

Laboratory Data: The Question Remains .................................................................290 D. The “Multiple Hit” Hypothesis .................................................................................291