ABSTRACT
Lichenoid eruption (1991): Massa MC+, Cutis 48, 41 (1980): Hawk JLM, Clin Exp Dermatol 5, 93 (1976): Cochran REI+, Arch Dermatol 112, 1173 Lupus erythematosus (1982): Hughes GRV, BJM 284, 1358 (1976): Harrison T+, Postgrad Med 59, 241 Necrosis Pemphigus (1982): Ruocco V+, Arch Dermatol Res 274, 123 (1980): Godard W+, Ann Dermatol Venereol (French) 107, 1213 Peripheral edema Peripheral skin necrosis (sic) (1979): Gokal R+, BMJ 1, 721 (1979): Hoffbrand BI, BMJ 1, 1082 Photosensitivity (1979): Faure M+, Ann Dermatol Venereol (French) 106, 161 Phototoxicity (1992): Shelley WB+, Cutis 50, 182 (observation) Pruritus (1973): Almeyda J+, Br J Dermatol 88, 313 Psoriasis (1993): Halevy S+, J Am Acad Dermatol 29, 504 (1992): Raychaudhuri SP+, J Am Acad Dermatol 27, 787 (1990): Halevy S+, Arch Dermatol Res 283, 472 (1988): Heng MCY+, Int J Dermatol 27, 619 (1987): Altomare GF+, G Ital Dermatol Venereol (Italian) 122, 531 (1987): Savola J+, BMJ 295, 637 (1986): Abel EA+, J Am Acad Dermatol 15, 1007 (1986): Czernielewski J, Lancet 1, 808 (exacerbation) (1984): Arntzen K+, Acta Derm Venereol (Stockh) 64, 346 (1983): Kaur S+, Indian Heart J 35, 181 (1979): Faure M+, Ann Dermatol Venereol (French) 106, 161 (1979): Halevy S+, Cutis 24, 95 (1976): Enger E, Tidsskr Nor Laegeforen (Norwegian) 96, 1103 (1976): Jensen HA+, Acta Med Scand 199, 363 (1976): Wadskov S+, Ugeskr Laeger (Danish) 138, 784 (1975): Padfield PL+, BMJ 1, 626 Purpura (1966): Harris A, Am J Cardiol 18, 431 Pustular psoriasis (1988): Heng MCY+, Int J Dermatol 27, 619 (1985): Hu C-H+, Arch Dermatol 121, 1326 Rash (sic) (1-10%) Raynaud’s phenomenon
(1976): Marshall AJ+, BMJ 1, 1498 (59%) Sclerosis (1980): Graham JR, Trans Am Clin Climatol Assoc 92, 122 Stevens-Johnson syndrome (1990): Zukervar P+, J Toxicol Clin Exp (French) 10, 169 (1989): Mukul+, J Assoc Physicians India 37, 797 Systemic erythematous eruption (sic) (1975): Felix RH+, BMJ 1, 626 Toxic epidermal necrolysis (1977): van Ketel WG+, Ned Tijdschr Geneeskd (Dutch) 121, 1475 Toxicoderma (1981): Danilov LN, Vestn Dermatol Venerol (Russian) January 42 Urticaria (1983): Hannaway PJ+, N Engl J Med 308, 1536 (1983): Oliver R, Cent Afr J Med 29, 91 (1975): Seides SF+, Chest 67, 496 Xerosis
Hair Hair-alopecia
(1994): Friedman M, J Fam Pract 39, 114 (1983): Hödl ST, Z Hautkr (German) 58, 17. (1982): England JRF+, Aust Fam Physician 11, 225 (1979): Hilder RJ, Cutis 24, 63 (1977): Scribner MD, Arch Dermatol 113, 1303 (1973): Martin CM+, Am Heart J 86, 236 Hair-alopecia areata (2001): Vinson RP, El Paso, TX (from Internet) (observation) (from a single dose)
Nails Nails-discoloration
(1976): Jensen HA+, Acta Med Scand 199, 363 Nails-onycholysis (1983): Hödl ST, Z Hautkr (German) 58, 17. Nails-pitting (psoriasiform) (1976): Jensen HA+, Acta Med Scand 199, 363 Nails-thickening (1983): Hödl ST, Z Hautkr (German) 58, 17. (1979): Faure M+, Ann Dermatol Venereol (French) 106, 161
Other Anaphylactoid reactions
(1983): Hannaway PJ+, N Engl J Med 308, 1536 Cheilostomatitis (sic) (1977): Tangsrud SE+, BMJ 2, 1385 Dupuytren’s contracture
(1966): Coupland WW, Med J Aust 2, 137 Dysgeusia (2000): Zervakis J+, Physiol Behav 68, 405 Headache Myalgia Myopathy (1980): Uuisitupa M+, BMJ 1, 183 Oral ulceration (1980): Hawk JLM, Clin Exp Dermatol 5, 93 Paresthesias Peyronie’s disease (1981): Neumann HAM+, Dermatologica 162, 330 (1979): Pryor JP+, Lancet 1, 824 (1977): Osborne DR, Lancet 1, 1111 (1977): Wallis AA+, Lancet 2, 980 (1977): Yudkin JS, Lancet 2, 1355 (passim) (1966): Coupland WW, Med J Aust 2, 137 Serum sickness (1983): Yen MC+, Postgrad Med 74, 291 Tongue pigmentation (1975): Raleigh F, Drug Intell Clin Pharm 9, 455 Xerostomia
Trade name: Propylthiouracil (Wyeth) Other common trade names: Propacil; Propycil; Propyl-Thyracil; Tiotil Indications: Hyperthyroidism Category: Antithyroid Half-life: 1-5 hours Clinically important, potentially hazardous interactions with: anticoagulants,
dicumarol, warfarin
Reactions
Skin Acne
(1980): Vasily DB+, JAMA 243, 458 Adverse effects (sic) (1982): Pacini F+, J Endocrinol Invest 5, 403 Angioedema
(1980): Vasily DB+, JAMA 243, 458 (1970): Amrhein JA+, J Pediatr 76, 54 (1%) (1965): Shelley WB, Arch Dermatol 91, 165 Dermatitis (sic) (1993): Elias AN+, J Am Acad Dermatol 29, 78 Edema (<1%) Erythema nodosum (1985): Keren G+, Isr J Med Sci 21, 62 Exanthems (1987): Wing SS+, Can Med Assoc J 136, 121 (1982): Gammeltoft M+, Acta Dermatol Venereol (Stockh) 62, 171 (3-5%) (1980): Vasily DB+, JAMA 243, 458 (1972): Wiberg JJ+, Ann Intern Med 77, 414 (1970): Amrhein JA+, J Pediatr 76, 54 Exfoliative dermatitis (<1%) Lichenoid eruption (1967): Coleman WP, Med Clin North Am 51, 1073 Lupus erythematosus (1-10%) (1994): Sato-Matsumura KC+, J Dermatol 21, 501 (1992): Skaer TL, Clin Ther 14, 496 (1991): Alarcon-Segovia D+, Baillieres Clin Rheumatol 5, 1 (1989): Horton RC+, Lancet 2, 568 (1987): Wing SS+, Can Med Assoc J 136, 121 (20% ANA) (1985): Bulvik S+, Harefuah (Hebrew) 109, 13 (1983): Berkman EM+, Transfusion 23, 135 (1981): Searles RP+, J Rheumatol 8, 498 (1981): Takuwa N+, Endocrinol (Jpn) 28, 663 (1980): Condemi JJ, Geriatrics 35(3), 81 (1973): Hung W+, J Pediatr 82, 852 (1970): Amrhein JA+, J Pediatr 76, 54 (1966): Faber V+, Acta Med Scand 179, 257 (1964): Best MM+, J Ky Med Assoc 62, 47 Photosensitivity (1997): Ohtsuka M+, Eur Resp J 10, 1405 Pigmentation Pruritus (<1%) (1980): Vasily DB+, JAMA 243, 458 Purpura (1987): Wing SS+, Can Med Assoc J 136, 121 (1962): Walzer RA, Arch Dermatol 86, 826 Pyoderma gangrenosum (1999): Darben T+, Australas J Dermatol 40, 144 Rash (sic) (>10%) Rosacea (1980): Vasily DB+, JAMA 243, 458
Ulcerations (2002): Helfgott SM+, N Engl J Med 347(2), 122 (1987): Wing SS+, Can Med Assoc J 136, 121 Urticaria (<1%) (1980): Vasily DB+, JAMA 243, 458 (1970): Amrhein JA+, J Pediatr 76, 54 Vasculitis (<1%) (2002): Helfgott SM+, N Engl J Med 347(2), 122 (2000): Lopez-Marina V+, Med Clin (Barc) (Spanish) 114, 398 (2000): Otsuka S+, Br J Dermatol 142(4), 828 (1999): Gunton JE+, J Clin Endocrinol Metab 84(1), 13 (1998): Harper L+, Nephrol Dial Transplant 13, 455 (1998): Merkel PA, Curr Opin Rheumatol 10, 45 (1998): Miller RM+, Australas J Dermatol 39, 96 (1997): Kitahara T+, Clin Nephrol 47, 336 (1997): Yarman S+, Int J Clin Pharm Ther 35, 282 (1993): Dolman KM+, Lancet 342, 651 (1992): Stankus SJ+, Chest 102, 1595 (1992): Wolf D+, Cutis 49, 253 (1987): Carrasco MD+, Arch Intern Med 147, 1677 (1987): Wing SS+, Can Med Assoc J 136, 121 (1986): Gleisner A+, Rev Child Pediatr (Spanish) 57, 64 (1985): Cox NH+, Clin Exp Dermatol 10, 292 (1982): Gammeltoft M+, Acta Dermatol Venereol (Stockh) 62, 171 (1982): Reidy TJ+, South Med J 75, 1297 (1980): Vasily DB+, JAMA 243, 458 (1979): Houston BD+, Arthritis Rheum 22, 925 (1978): Griswold WR+, West J Med 128, 543 (1973): Hung W+, J Pediatr 82, 852 (1965): McCombs RP, JAMA 194, 1059 (1965): Shelley WB, Arch Dermatol 91, 165 (1962): Walzer RA, Arch Dermatol 86, 826 Veslcular eruptions (in newborn) (1980): Vasily DB+, JAMA 243, 458 (1977): Caplan RH+, Wis Med J 76, S88
Hair Hair-alopecia (<1%)
(1997): Ohtsuka M+, Eur Resp J 10, 1405 (1980): Vasily DB+, JAMA 243, 458 (1951): Clarke MLB, JAMA 147, 1711 Hair-depigmentation (1980): Vasily DB+, JAMA 243, 458
Other Ageusia (1-10%)
Dysgeusia (1-10%) (metallic taste) (1993): Elias AN+, J Am Acad Dermatol 29, 78 Headache Hypersensitivity (1999): Chastain MA+, J Am Acad Dermatol 41, 757 (1991): Fong PC+, Horm Res 35, 132 (1963): Walzer RA+, JAMA 184, 743 Myalgia Oral mucosal lesions (1970): Amrhein JA+, J Pediatr 76, 54 Oral ulceration (1979): Houston BD+, Arthritis Rheum 22, 925 (1970): Amrhein JA+, J Pediatr 76, 54 Paresthesias (<1%) Polyarthritis (2002): Helfgott SM+, N Engl J Med 347(2), 122
Indications: Heparin overdose Category: Heparin antagonist Duration of action: 2 hours
Reactions
Skin Angioedema
(1991): Roelofse JA+, Anesth Prog 38, 99 Exanthems (1989): Weiss ME+, N Engl J Med 320, 886 Flushing (<1%) Urticaria (1989): Weiss ME+, N Engl J Med 320, 886
Other Anaphylactoid reactions
(1991): Roelofse JA+, Anesth Prog 38, 99 (1988): Oswald-Mammosser M+, Rev Fr Allergol (French) 28, 173 Death (2002): Kimmel SE+, Anesth Analg 94(6), 1402 Hypersensitivity (<1%)
