TACRINE

Synonym: THA Trade name: Cognex (First Horizon) Indications: Dementia of Alzheimer’s disease Category: Anticholinesterase; Cholinergic Half-life: 1.5-4 hours Clinically important, potentially hazardous interactions with: fluvoxamine,

galantamine

Reactions

Skin Acne (<1%)

Basal cell carcinoma Bullous eruption Cellulitis Cyst (sic) Dermatitis (sic) (<1%) Desquamation (sic) Diaphoresis Eczema (sic) Edema (<1%) Exanthems (7%) Facial edema (<1%) Flushing (3%) Furunculosis (<1%) Herpes simplex (<1%) Herpes zoster (<1%) Melanoma (<1%) Necrosis (<1%) Peripheral edema (<1%) Petechiae Pruritus (7%) Psoriasis (<1%) Purpura (2%) Rash (sic) (7%) Seborrhea Squamous cell carcinoma Ulcerations (<1%)

Urticaria (7%) Xerosis (<1%)

Hair Hair-alopecia (<1%)

Other Dysgeusia (<1%)

Gingivitis (<1%) Glossitis (<1%) Headache Myalgia (9%) Paresthesias (<1%) Parkinsonism (1999): Cabeza-Alvarez CI+, Neurologia (Spanish) 14, 96 Sialorrhea (<1%) Stomatitis (<1%) Tremor (1-10%) Xerostomia (<1%)

Synonym: FK506 Trade names: Prograf (Fujisawa); Protopic (Fujisawa) Indications: Prophylaxis of organ rejection, atopic dermatitis (topical) Category: Immunosuppressant; Topical for atopic dermatitis Half-life: ~8.7 hours Clinically important, potentially hazardous interactions with: beta-blockers,

cyclosporine, danazol, erythromycin, grapefruit juice, HMG-CoA reductase inhibitors, ibuprofen, immunosuppressants, ketoconazole, lovastatin, mycophenolate, potassium, potassium-sparing diuretics, rifabutin, rifampin, rifapentine, simvastatin, vaccines

Reactions

Skin Burning

(2002): Rozycki TW+, J Am Acad Dermatol 46, 27 (2002): Russell JJ, Am Fam Physician 66(10), 1899 (2001): Goldman D, J Am Acad Dermatol 44, 995 (transient, localized) (2000): Reitamo S+, Arch Dermatol 136, 999 (46.8%) (1999): Ruzicka R+, Arch Dermatol 135, 574

(1998): Alaiti S+, J Am Acad Dermatol 38, 69 Connective tissue nevi (sic) (1999): Reed BR, Denver, CO (from Internet) (observation) (confirmed by biopsies) Diaphoresis (>3%) Ecchymoses (>3%) Edema (>10%) Erythema (2000): Reitamo S+, Arch Dermatol 136, 999 (12.3%) Erythema (facial) (2001): Bohannon JS, Midlothian, VA (from Internet) (observation) (from topical)

(following wine) Exanthems (2001): Takamatsu Y+, Bone Marrow Transplant 28(4), 421 (with cyclosporine) (2000): Reitamo S+, Arch Dermatol 136, 999 (4.1%) Flushing (2000): Reitamo S+, Arch Dermatol 136, 999 (1997): Sandborn WJ, Am J Gastroenterol 92, 876 Folliculitis (2000): Reitamo S+, Arch Dermatol 136, 999 (10.8%) Herpes simplex (2000): Reitamo S+, Arch Dermatol 136, 999 (13%) Infections (sic) (>10%) Irritation (2002): Rozycki TW+, J Am Acad Dermatol 46(1), 27 Peripheral edema (26%) Photosensitivity (>3%) Pigmentation (2002): Phillips R, Melbourne, AU (from Internet) (observation) Pruritus (36%) (2002): Russell JJ, Am Fam Physician 66(10), 1899 (2000): Emre S+, Transpl Int 13, 73 (2000): Reitamo S+, Arch Dermatol 136, 999 (25.3%) Purpura (1996): Nash RA+, Blood 88, 3634 Pustules (2000): Reitamo S+, Arch Dermatol 136, 999 (6.3%) Rash (sic) (24%) Squamous cell carcinoma (2001): Otley CC+, Arch Dermatol 137, 459 Urticaria (2001): Takamatsu Y+, Bone Marrow Transplant 28(4), 421 (with cyclosporine)

Hair Hair-alopecia (>3%)

(1999): Ushigome H+, Transplant Proc 31, 2885 (2 cases)

(1998): Shapiro R+, Transplantation 65, 1284 (1997): Talbot D+, Transplantation 64, 1631 Hair-growth (sic) (1994): Yamamoto S+, J Dermatol Sci 7, S47 Hair-hirsutism

Other Anaphylactoid reactions (<1%)

(2001): Takamatsu Y+, Bone Marrow Transplant 28(4), 421 (with cyclosporine) Application-site burning (1997): Ruzicka T+, N Engl J Med 337, 816 Dysphagia (>3%) (2001): Hernandez G+, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92(5),

526 Gingival hyperplasia (2000): Schmutz J+, Ann Dermatol Venereol (French) 127, 646 (1998): Basile C+, Nephrol Dial Transplant 13, 2980 Headache Hyperesthesia Myalgia (>3%) Oral candidiasis (>3%) Oral ulceration (2001): Hernandez G+, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92(5),

526 (2001): Macario-Barrel A+, Ann Dermatol Venereol 128(12), 1327 Paresthesias (40%) (1997): Sandborn WJ, Am J Gastroenterol 92, 876 (1996): Arch Dermatol 132, 419 Tremor (>10%)

Trade name: Nolvadex (AstraZeneca) Other common trade names: Apo-Tamox; Bilim; Istubol; Kessar; Mamofen;

Novofen; Tamaxin; Tamofen; Tamoxan; Taxus; Valodex Indications: Advanced breast cancer Category: Antiestrogen; Antineoplastic estrogen receptor Half-life: 7 days Clinically important, potentially hazardous interactions with: black cohosh, dong

quai, ginseng

Reactions

Skin Dermatomyositis

(1982): Harris AL+, BMJ 284, 1674 Diaphoresis (1986): Buchanan RB+, J Clin Oncology 4, 1326 (1980): Pritchard KI+, Cancer Treat Rep 64, 787 Edema (3.8%) (1986): Buchanan RB+, J Clin Oncology 4, 1326 (1978): Heel RC+, Drugs 16, 1 (2-6%) Exanthems (1999): Descamps V+, Ann Dermatol Venereol (French) 126, 716 (1980): Pritchard KI+, Cancer Treat Rep 64, 787 (1978): Heel RC+, Drugs 16, 1 (3.6%) Flushing (>10%) (1999): Drayton G, Los Angeles, CA (from Internet) (observation) (1992): Shelley WB+, Advanced Dermatologic Diagnosis WB Saunders, 583 (passim) (1989): Buckley MMT+, Drugs 37, 451 (10-20%) (1986): Buchanan RB+, J Clin Oncology 4, 1326 (1981): Ingle JN+, N Engl J Med 304, 16 (29%) (1980): Pritchard KI+, Cancer Treat Rep 64, 787 (1978): Heel RC+, Drugs 16, 1 (14%) (1977): Kiang DT+, Ann Intern Med 87, 687 (21%) (1973): Ward HWC, BMJ 1, 13 (12%) Hot flashes (2002): Kinsinger LS+, Ann Intern Med 137(1), 59 (2001): Vogel NE+, Ned Tijdschr Geneeskd 145(22), 1041 Peripheral edema Pruritus (1980): Pritchard KI+, Cancer Treat Rep 64, 787 Pruritus vulvae (1980): Pritchard KI+, Cancer Treat Rep 64, 787 (1978): Heel RC+, Drugs 16, 1 (2-3%) Purpura (1978): Heel RC+, Drugs 16, 1 Radiation recall (1999): Bostrom A+, Acta Oncol 38, 955 (1992): Parry BR, Lancet 340, 49 Rash (sic) (1-10%) Urticaria Vaginal pruritus Vasculitis (1994): Rzany B+, J Am Acad Dermatol 30, 509

(1990): Drago F+, Ann Intern Med 112, 965 Xerosis (1978): Heel RC+, Drugs 16, 1 (7%)

Hair Hair-alopecia

(2001): Puglisi F+, Ann Intern Med 134(12), 1154 (total) (1993): Litt JZ, Beachwood, OH (personal case) (observation) (1980): Pritchard KI+, Cancer Treat Rep 64, 787 (1978): Heel RC+, Drugs 16, 1 (2%) Hair-color change (sic) (1995): Hampson JP+, Br J Dermatol 132, 483 Hair-hirsutism (1980): Pritchard KI+, Cancer Treat Rep 64, 787 Hair-hypertrichosis

Other Depression

(2001): Day R+, J Natl Cancer Inst 93(21), 1615 Dysgeusia Galactorrhea (1-10%) Headache Myopathy (1982): Harris AL+, BMJ 284, 1674 Thrombophlebitis (1996): Zimmet S, The Schoch Letter 46, 22 (#86) (observation) Xerostomia (1978): Heel RC+, Drugs 16, 1 (7%)

Trade name: Flomax (Boehringer Ingelheim) Indications: Benign prostatic hypertrophy Category: Selective alpha-blocker Half-life: 9-13 hours

Reactions

Skin Angioedema

Eczema (sic)

(2000): Frederickson KS, Novalo, CA (from Internet) (observation) Erythema multiforme (1999): Reed BR, Denver, CO (from Internet) (observation) Pruritus Rash (sic)

Other Headache

Tooth disorder (sic)

Synonyms: Acid Yellow T; Acilan Yellow GG; Cake Yellow; Tartar Yellow S; Wool Yellow

Trade names: E102; FD&C yellow No.5 Category: Food colorant Half-life: N/A

Reactions

Skin Adverse effects (sic)

(1986): Stevenson DD+, J Allergy Clin Immunol 78(1 Pt 2), 182 (1982): Rosenhall L, Eur J Respir Dis 63(5), 410 (1981): Neumann CJ+, Am J Hosp Pharm 38(6), 790, 792 Allergic reactions (sic) (2000): Bhatia MS, J Clin Psychiatry 61(7), 473 (1989): Pollock I+, BMJ 299(6700), 649 (1988): McLean JD, Can J Psychiatry 33(4), 331 (1987): Pohl R+, Am J Psychiatry 144(2), 237 (in antidepressents) (1982): MacCara ME, Can Med Assoc J 126(8), 910 (1979): Pellegrin A, Ann Med Interne (Paris) (French) 130(4), 211 (1977): Zlotlow MJ+, Am J Clin Nutr 30(7), 1023 (aspirin intolerance) Angioedema (1996): Jimenez-Aranda GS+, Rev Alerg Mex (Spanish) 43(6), 152 (1992): Novembre E+, Pediatr Med Chir (Italian) 14(1), 39 (passim) (1989): Hong SP+, Yonsei Med J 30(4), 339 (1989): Montano Garcia ML+, Rev Alerg Mex (Spanish) 36(1), 15 (1989): Montano Garcia ML, Rev Alerg Mex (Spanish) 36(3), 107 (1985): Collins-Williams C, J Asthma 22(3), 139 (aspirin intolerance) (1984): Diez Gomez ML+, Allergol Immunopathol (Madr) (Spanish) 12(3), 179

(1981): Alvarez Cuesta E+, Allergol Immunopathol (Madr) (Spanish) 9(1), 45 (1980): Makol GM+, Ariz Med 37(2), 79 (1978): Mikkelsen H+, Arch Toxicol Suppl Suppl 1, 141 Atopic dermatitis (2001): Worm M+, Clin Exp Allergy 31(2), 265 (1992): Devlin J+, Arch Dis Child 67(6), 709 Dermatitis (1990): Dipalma JR, Am Fam Physician 42(5), 1347 Edema (1989): Pachor ML+, Oral Surg Oral Med Oral Pathol 67(4), 393 Fixed eruption (1997): Orchard DC+, Australas J Dermatol 38(4), 212 Photosensitivity (1978): Meneghini CL+, Z Hautkr (German) 53(10), 329 Pruritus (1981): Alvarez Cuesta E+, Allergol Immunopathol (Madr) (Spanish) 9(1), 45 (1978): Neuman I+, Clin Allergy 8(1), 65 Purpura (1999): Kalinke DU+, Hautarzt (German) 50(1), 47 (1993): Wuthrich B, Ann Allergy 71(4), 379 (1990): Dipalma JR, Am Fam Physician 42(5), 1347 (1985): Parodl G+, Dermatologica 171(1), 62 (1981): Alvarez Cuesta E+, Allergol Immunopathol (Madr) (Spanish) 9(1), 45 Rash (sic) (1995): Thuvander A, Lakartidningen (Swedish) 92(4), 296 Urticaria (often related to aspirin intolerance) (1996): Jimenez-Aranda GS+, Rev Alerg Mex (Spanish) 43(6), 152 (1993): Wuthrich B, Ann Allergy 71(4), 379 (1992): Novembre E+, Pediatr Med Chir (Italian) 14(1), 39 (1990): Dipalma JR, Am Fam Physician 42(5), 1347 (1989): Baumgardner DJ, Postgrad Med 85(6), 265 (1989): Hong SP+, Yonsei Med J 30(4), 339 (1989): Montano Garcia ML+, Rev Alerg Mex (Spanish) 36(1), 15 (1989): Montano Garcia ML, Rev Alerg Mex (Spanish) 36(3), 107 (1989): Wilson N+, Clin Exp Allergy 19(3), 267 (1987): Settipane GA, N Engl Reg Allergy Proc 8(1), 39 (aspirin intolerance) (1986): Chudwin DS+, Ann Allergy 57(2), 133 (aspirin intolerance) (1986): Simon RA, N Engl Reg Allergy Proc 7(6), 533 (1986): Warrington RJ+, Clin Allergy 16(6), 527 (1985): Collins-Williams C, J Asthma 22(3), 139 (aspirin Intolerance) (1985): Podell RN, Postgrad Med 78(8), 83, 87, 92 (1984): Diez Gomez ML+, Allergol Immunopathol (Madr) (Spanish) 12(3), 179 (1984): Royal College of Physicians and the British Nutrition Foundation, J Royal

College of Physicians of London 18(2) (1982): Ortolani C+, Ann Allergy 48(1), 50

(1982): Warin RP+, Br Med J (Clin Res Ed) 284(6327), 1443 (1981): Alvarez Cuesta E+, Allergol Immunopathol (Madr) (Spanish) 9(1), 45 (1981): Juhlin L, Br J Dermatology 104, 369 (1981): Wuthrich B+, Schweiz Med Wochenschr 111(39), 1445 (6.1%) (1980): Makol GM+, Ariz Med 37(2), 79 (1980): Valverde E+, Clin Allergy 10(6), 691 (1979): Lindemayr H+, Wien Klin Wochenschr (German) 91(24), 817 (1978): Mikkelsen H+, Arch Toxicol Suppl 1, 141 (1978): Neuman I+, Clin Allergy 8(1), 65 (1977): Lockey SD Sr, Ann Allergy 38(3), 206 (aspirin intolerance) (1977): Warin RP, Hautarzt (German) 28(10), 511 (1976): Settipane GA+, J Allergy Clin Immunol 57(6), 541 (aspirin intolerance) (1975): Doeglas HM, Br J Dermatol 93(2), 135 (aspirin intolerance) (1974): Noid HE+, Arch Dermatology 109, 866 (1972): Juhlin L+, Allergy and Clin Immunol 50, 92 Vasculitis (1999): Kalinke DU+, Hautarzt (German) 50(1), 47 (1993): Wuthrich B, Ann Allergy 71(4), 379 (1990): Dipalma JR, Am Fam Physician 42(5), 1347

Other Anaphylactoid reactions

(1993): Wuthrich B, Ann Allergy 71(4), 379 (1989): Montano Garcia ML, Rev Alerg Mex (Spanish) 36(3), 107 (1981): Desmond RE+, Ann Allergy 46(2), 81 (1981): Schneiweiss F, Ann Allergy 46(5), 294 (1980): Kallos P+, Med Hypotheses 6(5), 487 (1978): Trautlein JJ+, Ann Allergy 41(1), 28 (1977): Morris SJ+, Arch Intern Med 137(9), 1222 Arthralgia (1992): Novembre E+, Pediatr Med Chir (Italian) 14(1), 39 Asthenia (1978): Neuman I+, Clin Allergy 8(1), 65 Depression (1992): Novembre E+, Pediatr Med Chir (Italian) 14(1), 39 Gingival hypertrophy (1989): Pachor ML+, Ord Surg Oral Med Oral Pathol 67(4), 393 Hypersensitivity (1995): Sakakibara H+, Nihon Kyobu Shikkan Gakkai Zasshi (Japanese) 33, 106 (1995): Thuvander A, Lakartidningen (Swedish) 92(4), 296 (1980): Weliky N+, Clin Allergy 10(4), 375 (1979): Weliky N+, Immunol Commun 8(1), 65 (1978): Berglund F, Arch Toxicol Suppl 1, 33 (1978): Mikkelsen H+, Arch Toxicol Suppl 1, 141 (1976): Rosenhall L+, Bull Int Union Tuberc 51(1), 515 (aspirin intolerance)

(1976): Stenius BS+, Clin Allergy 6(2), 119 (aspirin intolerance) (1975): Rosenhall L+, Tubercle 56(2), 168 (aspirin intolerance) Paresthesias (1981): Alvarez Cuesta E+, Allergol Immunopathol (Madr) (Spanish) 9(1), 45 Serum sickness (1978): Wolfe MS+, Am J Trop Med Hyg 27(4), 762 Note: Tartrazine intolerance has been estimated to affect between 0.01% and 0.1% of

the population. Adverse reactions are most common in people who are sensitive to aspirin. Banned in Norway and Austria

Scientific names: Cordyline australis; Leptospermum scoparium; Melaleuca alternifolia; Melaleuca cajeputi; Melaleuca dissitifolia; Melaleuca linafolia

Family: Myrtaceae Trade and other common names: Amber Gold; Australian Tea Tree; Burnaid;

Cajuput; Dessert Essence; Melasol; New Zealand Manuka,; New Zealand Ti-Tree; Teatree oil

Category: Acaricide; Antifungal; Antimicrobial; Antiviral; Topical antiseptic Purported indications and other uses: Gram-negative and Gram-positive bacteria,

acne, vaginal infection, burns, onychomycosis, tinea pedis, bruises, insect bites, skin infections, mouthwash, genital herpes, antiperspirant, gingivitis, disinfectant, scabies

Half-life: N/A Clinically important, potentially hazardous interactions with: colophony,

turpentine

Reactions

Skin Adverse effects

(2002): Haller CA+, Adverse Drug React Toxicol Rev 21(3), 143 Allergic reactions (sic) (2002): Haller CA+, Adverse Drug React Toxicol Rev 21(3), 143 (2000): Ernst E+, Forsch Komplementarmed Klass Naturheilkd 7(1), 17 (2000): Thomson KF+, Br J Dermatol 142, 84 (2000): Varma S+, Contact Dermatitis 42(5), 309 (1997): Hackzell-Bradley M+, Lakartidningen 94(47), 4359 (1994): Selvaag E+, Contact Dermatitis 31(2), 124 (1993): de Groot AC+, Contact Dermatitis 28(5), 309 Burning (2002): Groppo FC+, Int Dent J 52(6), 433

Dermatitis (2003): Perrett CM+, Clin Exp Dermatol 28(2), 167 (2002): Schempp CM+, Hautarzt 53(2), 93 (2001): Fritz TM+, Ann Dermatol Venereol 128(2), 123 (7 cases) (2000): Khanna M+, Am J Contact Dermat 11(4), 238 (1999): Bruynzeel DP, Trop Med Int Health 4(9), 630 (1999): Greig JE+, Contact Dermatitis 41(6), 354 (1999): Hausen BM+, Am J Contact Dermat 10(2), 68 (1998): Rubel DM+, Australas J Dermatol 39(4), 244 (1998): Wolner-Hanssen P+, Lakartidningen 95(30), 3309 (1997): Bhushan M+, Contact Dermatitis 36(2), 117 (1997): Kranke B, Hautarzt 48(3), 203 (1996): De Groot AC, Contact Dermatitis 35(5), 304 (1994): Knight TE+, J Am Acad Dermatol 30(3), 423 (1994): van der Valk PG+, Ned Tijdschr Geneeskd 138(16), 823 (4 cases) (1992): de Groot AC+, Contact Dermatitis 27(4), 279 (1991): Apted JH, Australas J Dermatol 32(3), 177 Eczema (2002): Dharmagunawardena B+, Contact Dermatitis 47(5), 288 Erythema multiforme (2000): Khanna M+, Am J Contact Dermat 11(4), 238 Inflammation (1999): Syed TA+, Trop Med Int Health 4(4), 284 (4 cases) (with butenafine) Linear IgA dermatosis (2003): Perrett CM+, Clin Exp Dermatol 28(2), 167 Pruritus (1998): Wolner-Hanssen P+, Lakartidningen 95(30), 3309 Rash (sic) Sensitization (1999): Hausen BM+, Am J Contact Dermat 10(2), 68 Toxicity (sic) (1995): Carson CF+, J Toxicol Clin Toxicol 33(2), 193

Other Ataxia

(1995): Del Beccaro, Vet Hum Toxicol 37(6), 557 (ingested) Confusion (1994): Jacobs MR+, J Toxicol Clin Toxicol 32(4), 461 (ingested) Depression (1994): Villar D+, Vet Hum Toxicol 36(2), 139 (ingested) Hypersensitivity (2003): Mozelsio NB+, Allergy Asthma Proc 24(1), 73 (2001): Fritz TM+, Ann Dermatol Venereol 128(2), 123 (7 cases) Side effects (2000): Ernst E, Br J Dermatol 143(5), 923

Tremor (1994): Villar D+, Vet Hum Toxicol 36(2), 139 Note: Tea tree oil in bottles may undergo photooxidation, and degradation products are

moderate to strong sensitizers. The plant was discovered and named by Captain James Cook of the Royal Navy in

1770, who found groves of trees with sticky, aromatic leaves that, when boiled, made a spicy tea

Trade name: Zelnorm (Novartis) Indications: Irritable bowel syndrome Category: Serotonin 5-HT4 receptor agonist Half-life: 11±5 hours

Reactions

Skin Diaphoresis

Facial edema Flushing Pruritus

Other Back pain (5%)

Breast carcinoma Depression Dizziness (4%) Headache (2003): Kellow J+, Gut 52(5), 671 (12%) Limb pain (1%) Mouth vesiculation Pain

Trade name: Micardis (Boehringer Ingelheim)

Indications: Hypertension Category: Angiotensin II receptor antagonist; Antihypertensive Half-life: 24 hours

Reactions

Skin Allergic reactions (sic) (<1%)

Angioedema (>0.3%) Dermatitis (sic) (>0.3%) Diaphoresis (>0.3%) Eczema (sic) (>0.3%) Edema (2001): Lacourciere Y+, J Hum Hypertens 15(11), 763 Edema of leg (>0.3%) Flu-like syndrome (sic) (1%) Flushing (>0.3%) Fungal infections (sic) (>0.3%) Peripheral edema (1%) Pruritus (>0.3%) Rash (sic) (>0.3%)

Other Hyperesthesia (>0.3%)

Myalgia (1%) Paresthesias (>0.3%) Xerostomia (>0.3%)

Trade names: Restoril (Mallinckrodt); Temazepam Other common trade names: Apo-Temazepam; Cerepax; Euhypnos; Lenal;

Levanxene; Normison; Nu-Temazepam; Planum Indications: Insomnia, anxiety Category: Benzodiazepine sedative-hypnotic Half-life: 8-15 hours Clinically important, potentially hazardous interactions with: amprenavir,

chlorpheniramine, clarithromycin, efavirenz, esomeprazole, imatinib, nelfinavir

Reactions

Skin Adverse effects (sic)

(1984): Stricker BH, Ned Tijdschr Geneeskd (Dutch) 128, 870 Bullous eruption (1999): Verghese J+, Acad Emerg Med 6, 1071 Dermatitis (sic) (1-10%) Diaphoresis (>10%) Exanthems Fixed eruption (1988): Archer CB+, Clin Exp Dermatol 13, 336 Lichenoid eruption (1986): Norris P+, BMJ 293, 510 Pruritus Purpura Rash (sic) (>10%) Urticaria

Other Anaphylactoid reactions

(1988): Mills PJ, Anaesthesia 43, 66 Dysgeusia Headache Paresthesias Sialopenia (>10%) Sialorrhea (1-10%) Tremor (<1%) Xerostomia (1.7%)

Trade name: Temodar (Schering) Indications: Anaplastic astrocytoma Category: Antineoplastic Half-life: 1.8 hours

Reactions

Skin Edema

(2003): Hwu W-J, J Drugs Dermatol 2, 53 (with thalidomide)

Infections (sic) (2003): Hwu W-J, J Drugs Dermatol 2, 53 (with thalidomide) Peripheral edema (11%) Pruritus (8%) Rash (sic) (8%) (2003): Hwu W-J, J Drugs Dermatol 2, 53 (with thalidomide) Viral infections (sic) (11%)

Other Headache

Mastodynia (6%) Myalgia (5%) Paresthesias (9%) Tremor (2003): Hwu W-J, J Drugs Dermatol 2, 53 (with thalidomide)

Trade name: TNKase (Genentech) Indications: Acute myocardial infarction Category: Recombinant tissue plasminogen activator; Thrombolytic Half-life: 90-130 minutes Clinically important, potentially hazardous interactions with: bivalirudin

Reactions

Skin Angioedema (<1%)

Ecchymoses Hematomas (local) (12%) Livedo reticularis (<1%) Purple glove syndrome (<1%) Purpura Rash (sic) (<1%) Urticaria (<1%)

Other Anaphylactoid reactions (<1%)

Gangrene (<1%) Rhabdomyolysis (<1%)