CETRORELIX

Trade name: Cetrotide (Serono) Indications: Inhibition of premature luteinizing hormone surges in women undergoing

controlled ovarian stimulation Category: Antigonadotropic Half-life: 5 hours

Reactions

Skin Peripheral edema

Other Anaphylactoid reactions

Injection-site edema Injection-site erythema (1994): Leroy I+, Fertil Steril 62, 461 Injection-site pruritus (1994): Leroy I+, Fertil Steril 62, 461 Injection-site purpura

Trade name: Exovac (SnowBrand) Indications: Sicca syndrome in patients with Sjøgren’s syndrome Category: Cholinergic; Muscarinic agonist Half-life: 3-4 hours

Reactions

Skin Allergic reactions (sic) (1-10%)

Bullous eruption (<1%) Dermatitis (sic) (<1%) Diaphoresis (20%)

Eczema (<1%) Edema (1-10%) Exanthems (1-10%) Flu-like syndrome (sic) (1-10%) Fungal infections (sic) (1-10%) Genital pruritus (<1%) Hot flashes (2%) Peripheral edema (1-10%) Photosensitivity (<1%) Pruritus (1-10%) Rash (sic) (4%) Ulcerations (<1%) Vasculitis (<1%) Xerosis (<1%)

Hair Hair-alopecia (<1%)

Other Dysgeusia (<1%)

Gingival hyperplasia (<1%) Headache Hyperesthesia (1-10%) Myalgia (1-10%) Paresthesias (<1%) Parosmia (<1%) Sialorrhea (2%) Stomatitis (<1%) Tendinitis (<1%) Thrombophlebitis (<1%) Tongue discoloration (<1%) Tongue ulceration (<1%) Tooth disorder (sic) (1-10%) Tremor (1-10%) Ulcerative stomatitis (1-10%) Vaginitis (1-10%) Xerostomia (1-10%)

Scientific names: Chamomilla recutita; Matricaria chamomilla; Matricaria recutita Family: Asteraceae; Compositae

Trade and other common names: Camomille; German Chamomile; Manzanilla; Pin Heads

Category: Sedative; Stomachic Purported indications and other uses: Flatulence, travel sickness, nervous diarrhea,

restlessness, menstrual cramps, hemorrhoids, mastitis, leg ulcers, inflammation of the respiratory tract. Used in flavoring, cosmetics, soaps and mouthwashes

Half-life: N/A Clinically important, potentially hazardous interactions with: warfarin

Reactions

Skin Allergic reactions (sic) (to those allergic to ragweed, marigolds, daisies)

Dermatitis (2002): Schempp CM+, Hautarzt 53(2), 93 (2000): Foti C+, Contact Dermatitis 42(6), 360 (2000): Giordano-Labadie F+, Contact Dermatitis 42(4), 247 Irritation Sensitization (2002): Paulsen E, Contact Dermatitis 47(4), 189

Other Anaphylactoid reactions

(2001): Thien FC, Med J Aust 175(1), 54 (from enema) (1989): Subiza J+, J Allergy Clin Immunol 84, 353 Hypersensitivity

Scientific name: Vitex agnus-castus Family: Verbenaceae Trade and other common names: Abraham’s Balm; Agno Casto; Agnocasto;

Agnolyt (Madaus); Bish Barmagh Aghaji; Chaste Lamb-Tree; Chaste tree*; Daribrahim; Gatilier; Hayit; Hemp Tree; Kaff Maryam; Keuschlamm; Lygos; Monks Pepper; Panjangusht; Ranukabija; Safe Tree; Sauzgatillo; Seiyo-Ninzin-Boku; Shajerat Ebrahim; Strotan; Vitex; Ze 440

Category: Hormonal modulator Half-life: N/A Clinically important, potentially hazardous interactions with: dopamine-receptor

antagonists

Reactions

Skin Abscess

(2001): Schellenberg R, BMJ 322(7279), 134 (mild) Acne (2001): Schellenberg R, BMJ 322(7279), 134 (mild) Adverse effects (sic) (2001): Schellenberg R, BMJ 322(7279), 134 (mild) (2000): Loch EG+, J Womens Health Gend Based Med 9(3), 315 (1.2%) Formication Itching Rash (sic) Urticaria (2001): Schellenberg R, BMJ 322(7279), 134 (mild)

Other Fatigue

(2000): Berger D+, Arch Gynecol Obstet 264(3), 150 Headache (2000): Berger D+, Arch Gynecol Obstet 264(3), 150 Note: Chasteberry is not a phytoestrogen, it appears to stimulate progesterone

production

*Note: The Catholic church once placed it in the pockets of neophyte monks to help them to maintain their vow of chastity

Scientific name: Cichorium intybus Family: Compositae Trade and other common names: Barbe de Capucin; Belgian endive; Hendibeh;

Succory; Wild Succory Category: Diuretic; Laxative; Tonic Purported indications and other uses: coffee substitute, jaundice, liver enlargement,

gout, rheumatism, skin eruptions connected with gout, inflammation. Topical: leaves used for swelling and inflammation. Culinary spice, flavoring

Half-life: N/A

Reactions

Skin Allergic reactions (sic)

(2003): Cadot P+, Int Arch Allergy Immunol 131(1), 19 (1997): Helbling A+, J Allergy Clin Immunol 99(6), 854 (1996): Cadot P+, Clin Exp Allergy 26(8), 940 Dermatitis (1983): Malten KE, Contact Dermatitis 9(3), 232

Synonyms: chloral; hydrated chloral Trade names: Aquachloral (Alcon); Noctec (Bristol-Myers Squibb) Other common trade names: Chloraldurat; Medianox; Novochlorhydrate; Somnox;

Welldorm Indications: Insomnia, sedation Category: Sedative-hypnotic Half-life: 8-11 hours Clinically important, potentially hazardous interactions with: antihistamines,

azatadine, azelastine, brompheniramine, buclizine, chlorpheniramine, clemastine, dexchlorpheniramine, diphenhydramine, meclizine, tripelennamine

Reactions

Skin Acne

(1967): Hitch JM, JAMA 200, 879 (1956): Christianson HB+, Arch Dermatol 74, 232 Angioedema (1973): Almeyda J+, Br J Dermatol 86, 313 (1956): Christianson HB+, Arch Dermatol 74, 232 Bullous eruption (1967): Coleman WP, Med Clin North Am 51, 1073 Dermatitis (sic) (1987): de Groot AC+, Contact Dermatitis 16, 229 (1956): Christianson HB+, Arch Dermatol 74, 232 Eczema (sic) (1956): Christianson HB+, Arch Dermatol 74, 232

Erythema (1956): Christianson HB+, Arch Dermatol 74, 232 Erythema multiforme (1991): Porteous DM+, Arch Dermatol 127, 740 (in AIDS) (1956): Christianson HB+, Arch Dermatol 74, 232 Exanthems (1990): Lindner K+, Dermatol Monatsschr (German) 176, 483 (1976): Arndt KA+, JAMA 235, 918 (0.02%) (1956): Christianson HB+, Arch Dermatol 74, 232 Fixed eruption (1973): Almeyda J+, Br J Dermatol 86, 313 (1972): Verbov J, Br J Dermatol 86, 438 (1966): Miller LH+, Arch Dermatol 94, 60 (1961): Welsh AL+, Arch Dermatol 84, 1004 (1956): Christianson HB+, Arch Dermatol 74, 232 Flushing (1956): Christianson HB+, Arch Dermatol 74, 232 Lichenoid eruption (1956): Christianson HB+, Arch Dermatol 74, 232 Perioral dermatitis (2001): Caksen H+, Pediatr Dermatol 18(5), 454 Pruritus (1990): Lindner K+, Dermatol Monatsschr (German) 176, 483 (1956): Christianson HB+, Arch Dermatol 74, 232 Purpura (1973): Almeyda J+, Br J Dermatol 86, 313 (1956): Christianson HB+, Arch Dermatol 74, 232 Rash (sic) (1-10%) Ulcerations (1956): Christianson HB+, Arch Dermatol 74, 232 Urticaria (1-10%) (1973): Almeyda J+, Br J Dermatol 86, 313 (1956): Christianson HB+, Arch Dermatol 74, 232

Other Acute intermittent porphyria

Death (2003): Thurau K+, Arch Kriminol 211(3), 90 (2001): Gaulier JM+, J Forensic Sci 46(6), 1507 (2 cases) Dysgeusia Headache Hypersensitivity Oral mucosal lesions (2001): Caksen H+, Pediatr Dermatol 18(5), 454 (1956): Christianson HB+, Arch Dermatol 74, 232

Oral ulceration (1956): Christianson HB+, Arch Dermatol 74, 232 Stomatitis (1956): Christianson HB+, Arch Dermatol 74, 232

Trade name: Leukeran (GSK) Other common trade names: Chloraminophene; Linfolysin Indications: Chronic lymphocytic leukemia, lymphomas, carcinomas Category: Antineoplastic Half-life: 1.5 hours Clinically important, potentially hazardous interactions with: aldesleukin,

antineoplastics, azathioprine, bone marrow suppressants, vaccines

Reactions

Skin Angioedema

(1977): Millard LG+, Arch Dermatol 113, 1298 Edema Edema of foot (1987): Schmutz JL+, Ann Dermatol Venereol (French) 114, 569 Erythema multiforme (1987): Hitchens RN+, Aust N Z J Med 17, 600 Exanthems (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,

289 (passim) (1987): Hitchens RN+, Aust N Z J Med 17, 600 (1986): Peterman A+, Arch Dermatol 122, 1358 (1978): Franchimont P+J, Rheumatol 5, 85 (1.3%) (1977): Millard LG+, Arch Dermatol 113, 1298 (1971): Knisely RE+, Arch Dermatol 104, 77 (1968): Vissian L+, Bull Soc Fr Dermatol Syphiligr (French) 75, 570 Exfoliative dermatitis (1987): Hitchens RN+, Aust N Z J Med 17, 600 Facial erythema (1986): Peterman A+, Arch Dermatol 122, 1358 Herpes simplex (1984): Sahgal SM+, J R Soc Med 77, 144 (1971): Degos R+, Bull Soc Fr Dermatol Syphiligr (French) 78, 631

Herpes zoster (2002): Goldstein DA+, Ophthalmology 109(2), 370 (1972): Decker JL, Ann Intern Med 76, 619 (>5%) Kaposi’s sarcoma (1974): Faye I+, Bull Soc Fr Dermatol Syphiligr (French) 81, 379 Lupus erythematosus (1986): Peterman A+, Arch Dermatol 122, 1358 Necrosis (1972): Decker JL, Ann Intern Med 76, 619 Periorbital edema (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,

289 (passim) (1986): Peterman A+, Arch Dermatol 122, 1358 (1977): Millard LG+, Arch Dermatol 113, 1298 Photosensitivity (1987): Schmutz JL+, Ann Dermatol Venereol (French) 114, 569 Pruritus (1971): Knisely RE+, Arch Dermatol 104, 77 (1968): Vissian L+, Bull Soc Fr Dermatol Syphiligr (French) 75, 570 Psoriasis (exacerbation) (1968): Vissian L+, Bull Soc Fr Dermatol Syphiligr (French) 75, 570 Purpura (1990): Pietrantonio F+, Cancer Lett 54, 109 Rash (sic) (1-10%) Sezary syndrome (1981): Ferme F+, Leuk Res 5, 169 Side effects (sic) (1968): Moore GE+, Cancer Chemother Abstr 52, 661 (20%) Stevens-Johnson syndrome Toxic epidermal necrolysis (1997): Aydogdu I+, Anticancer Drugs 8, 468 (1990): Barone C+, Eur J Cancer 26, 1262 (1990): Pietrantonio F+, Cancer Lett 54, 109 (1968): Vissian L+, Bull Soc Fr Dermatol Syphiligr (French) 75, 570 Urticaria (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,

289 (passim) (1977): Millard LG+, Arch Dermatol 113, 1298 (1971): Knisely RE+, Arch Dermatol 104, 77 (1968): Vissian L+, Bull Soc Fr Dermatol Syphiligr (French) 75, 570

Hair Hair-alopecia

(1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 289 (passim)

(1978): Franchimont P+, J Rheumatol 5, 85 (1.3%) (1978): Levine N+, Cancer Treat Rev 5, 67 (1973): Snaith ML+, BMJ 2, 197

Other Acute intermittent porphyria

Hypersensitivity (<1%) (1971): Knisley RE+, Arch Dermatol 104, 77 Oral mucosal lesions (1968): Moore GE+, Cancer Chemother Abstr 52, 661 (2%) Oral ulceration (<1%) (1987): Hitchens RN+, Aust N Z J Med 17, 600 Stomatitis

Trade names: AK-Chlor (Akorn); Chloromycetin (Parke-Davis); Chloroptic (Allergan); Ophthochlor (Parke-Davis)

Other common trade names:Aquamycetin; Cebenicol; Diochloram; Kloramfenicol; Oleomycetin; Pentamycetin; Sopamycetin; Tifomycine

Indications: Various infections caused by susceptible organisms Category: Broad-spectrum antibiotic Half-life: 1.5-3.5 hours Clinically important, potentially hazardous interactions with: amoxicillin,

ampicillin, ethotoin, fosphenytoin, mephenytoin, phenytoin

Reactions

Skin Acute generalized exanthematous pustulosis (AGEP)

(2000): Lee AY+, Acta Derm Venereol 79, 412 (1995): Moreau A+, Int J Dermatol 34, 263 (passim) Angioedema (<1%) (1985): Schewach-Millet M+, Arch Dermatol 121, 587 Bullous eruption (1963): Ory EM+, JAMA 185, 273 Dermatitis (sic) (2001): Sachs B+, Allergy 56(1), 69 (1998): Le Coz CJ+, Contact Dermatitis 38, 108 (face) (1996): Moyano JC+, Allergy 51, 67 (1992): Urrutia I+, Contact Dermatitis 26, 66

(1991): Vincenzi C+, Contact Dermatitis 25, 64 (1987): Kubo Y+, Contact Dermatitis 17, 245 (1987): Raulin C+, Derm Beruf Umwelt 35, 64 (1986): Rebandel P+, Contact Dermatitis 15, 92 (1986): van Joost T+, Contact Dermatitis 14, 176 (1985): Linss G+, Dermatol Monatsschr (German) 171, 250 (1978): Blondeel A+, Contact Dermatitis 4, 270 (1976): Rudzki E+, Contact Dermatitis 2, 181 (1975): Braun WP, Contact Dermatitis 1, 241 (1975): Wereide K, Contact Dermatitis 1, 271 (1973): Ebner H, Wien Klin Wochenschr (German) 85, 203 (1967): Schubert H, Allerg Asthma Leipz (German) 13, 25 (1966): Eberhartinger C+, Arch Klin Exp Dermatol (German) 224, 463 (1966): Korossy S+, Z Haut Geschlechtskr (German) 41, 375 Eczema (sic) Edema of foot Erythema multiforme (<1%) (1996): Lazarov A+, Cutis 58, 263 (from eyedrops) (1986): Fisher AA, Cutis 37, 158 (topical application) (1969): Ting HC+, Int J Dermatol 24, 587 (1967): Coleman WP, Med Clin North Am 51, 1073 (1965): Mathé P+, J Med Bordeaux (French) 42, 1367 (1965): Pieris EV, Ceylon Med J 10, 67 Exanthems (1-5%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,

157 (passim) (1972): Kauppinen K, Acta Derm Venereol (Stockh) 52, (Suppl) 68 (1969): Török H, Dermatol Int 8, 57 (1951): Altemeier WA+, JAMA 145, 489 (1.7%) (1951): Usndek HE+, Arch Dermatol 64, 217 Fixed eruption (1985): Pandhi RK+, Australasian J Dermatol 26, 88 Gray syndrome* Leucoderma (1980): Chalfin J+, Ophthalmic Surg 11, 194 (eyelid) Pruritus (<1%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,

157 (passim) Purpura (1967): Singh S+, Indian J Pediatr 4, 451 (1965): Horowitz HI+, Semin Hematol 2, 287 Pustules (1973): Macmillan AL, Dermatologica 146, 285 (1971): Stevanovic DN, Br J Dermatol 85, 134 Rash (sic) (<1%)

Sensitization (sic) (1992): Urrutia I+, Contact Dermatitis 26, 66 (1986): van Joost T+, Contact Dermatitis 14, 176 Sheet-like erythema Stevens-Johnson syndrome (1965): Pieris EV, Ceylon Med J 10, 67 Systemic eczematous contact dermatitis Toxic epidermal necrolysis (<1%) (1975): Munstermann M+, Dtsch Med Wochenschr (German) 100, 2337 (1965): Mathé P+, J Med Bord (French) 142, 1367 Urticaria (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,

157 (passim) (1987): Perkins JB+, Drug Intell Clin Pharm 21, 343 (1985): Schewach-Millet M+, Arch Dermatol 121, 587 Vasculitis (1965): McCombs RP, JAMA 194, 1059

Hair Hair-alopecia

(1977): Kapp JP+, Clinical Pediatrics 16, 64

Nails Nails-photo-onycholysis

(1985): Kechijian P, J Am Acad Dermatol 12, 552 (1984): Daniel CR+, J Am Acad Dermatol 10, 250

*Note: Gray syndrome: toxic reactions in premature infants and newborns. Signs and symptoms include: abdominal distension, bluegray skin color, low body temperature, and uneven breathing

Other Acute intermittent porphyria

Anaphylactoid reactions (1976): Kozakova M, Cesk Dermatol (Slovak) 51, 82 Black tongue (1954): Annotations, Lancet 2, 179 Glossitis (1951): Altemeier WA+, JAMA 145,489 Headache Hypersensitivity (1978): Simon N, Z Hautkr (German) 53, 341 (1974): Hegyi E+, Cesk Dermatol (Slovak) 49, 96 Oral mucosal eruption (1951): Altemeier WA+, JAMA 145, 489 Oral ulceration Paresthesias

(1988): Ramilo O+, Pediatr Infect Dis 7, 358 Porphyria (1976): Panica D+, Folia Med Plovdiv 18, 161 Stomatitis (<1%) Xerostomia

Trade names: Libritabs (ICN); Librium (ICN); Limbitrol (ICN) Other common trade names: Corax; Huberplex; Medilium; Mitran; Multum;

Novopoxide; Psicofar; Reposans-10; Solium; Tropium Indications: Anxiety Category: Antianxiety; Antipanic; Antitremor; Benzodiazepine sedative-hypnotic Half-life: 6-25 hours Clinically important, potentially hazardous interactions with: chlorpheniramine,

clarithromycin, efavirenz, esomeprazole, imatinib, indinavir, ketoconazole, nelfinavir, ritonavir

Limbitrol is amitriptyline and chlordiazepoxide

Reactions

Skin Angioedema (<1%)

(1971): Almeyda J, Br J Dermatol 84, 299 (1964): Welsh AL, Med Clin North Am 48, 459 Dermatitis (sic) (1-10%) Diaphoresis (>10%) Edema (1-10%) Erythema multiforme (<1%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,

200 (passim) (1985): Kauppinen K+, Br J Dermatol 112, 575 (1981): Edwards JG, Drugs 22, 495 (passim) (1974): Tay C, Asian J Med 10, 223 (1971): Almeyda J, Br J Dermatol 84, 299 Erythema nodosum (<1%) (1981): Edwards JG, Drugs 22, 495 (passim) (1971): Almeyda J, Br J Dermatol 84, 299 Exanthems (1976): Arndt KA+, JAMA 235, 918 (0.42%) (1971): Almeyda J, Br J Dermatol 84, 299

Fixed eruption (<1%) (1990): Gaffoor PMA+, Cutis 45, 242 (passim) (1981): Edwards JG, Drugs 22, 495 (passim) (1974): Blair HM, Arch Dermatol 109, 914 (1970): Savin JA, Br J Dermatol 83, 546 (1964): Welsh AL, Med Clin North Am 48, 459 (1961): Gaul LE, Arch Dermatol 83, 1010 Lupus erythematosus (1973): Hicks JH, Cutis 11, 33 (1973): McCarthy J, Arch Dermatol 108, 733 (discussion) (1965): Grupper CH+, Bull Soc Franc Derm Syphiligr (French) 72, 714 Photosensitivity (1986): Morliere P, Biochemie 68, 849 (1981): Edwards JG, Drugs 22, 495 (passim) (1980): Bjellerup M+, J Invest Dermatol 75, 228 (1973): Torre D, Arch Dermatol 108, 733 (discussion) (1971): Almeyda J, Br J Dermatol 84, 299 (1965): Luton EF+, Arch Dermatol 91, 362 Pigmented purpuric eruption (1989): Nishioka K+, J Dermatol (Tokio) 16, 220 Pruritus (1977): Ghosh JS, BMJ 1,902 Purpura (2001): Alexopoulou A+, Arch Intern Med 161 (14), 1778 (with clidinium) (1981): Edwards JG, Drugs 22, 495 (passim) (1977): Celada A+, BMJ 1, 268 (1971): Almeyda J, Br J Dermatol 84, 299 (1967): Copperman IJ, BMJ 4, 485 Rash (sic) (>10%) (1960): Tobin JM, JAMA 174, 1242 Urticaria (1981): Edwards JG, Drugs 22, 495 (passim) (1974): Tay C, Asian J Med 10, 223 (1971): Almeyda J, Br J Dermatol 84, 299 (1964): Welsh AL, Med Clin North Am 48, 459 Vasculitis (1989): Nishioka K+, J Dermatol 16, 220 (1971): Almeyda J, Br J Dermatol 84, 299

Hair Hair-alopecia

(1977): Celada A+, BMJ 1, 268 (1973): Hicks JH, Cutis 11, 33 (1965): Luton EF+, Arch Dermatol 91, 362

Other

Acute intermittent porphyria (1967): de Matteis F, Pharmacol Rev 19, 523 Galactorrhea (1971): Almeyda J, Br J Dermatol 84, 299 (1961): Hooper JH+, JAMA 178, 506 (1956): Marshall WK+, Lancet 1, 152 Gynecomastia (1965): Vavala V+, Endocr Metabol 36, 43 Headache Injection-site phlebitis Paresthesias Porphyria (1983): Eubanks SW+, Int J Dermatol 22, 337 Sialopenia (>10%) Sialorrhea (1-10%) Xerostomia (>10%)

Trade names: BactoShield; Betasept (Purdue Frederick); DynaHex; Exidine Scrub; Hibiclens (Regent); Hibistat; Peridex; PerioChip; Periogard

Other common trade names:Alcloxidine; Bactoscrub; Chlorhexamed; Corsodyl; Hexol; Hibident; Hibidil; Hibiscrub; Hibitane; Savlon; Spectro Gram

Indications: Skin antisepsis, gingivitis Category: Topical anti-infective Half-life: N/A

Reactions

Skin Allergic reactions (sic)

(2003): Jayathillake A+, Urology 61(4), 837 (2001): Garvey LH+, Acta Anaesthesiol Scand 45(10), 1290 (4 cases) (1995): Yong D+, Med J Aust 162, 257 (1992): Ramselaar CG+, Br J Urol 70, 451 (1985): Cheung J+, Anaesth Intensive Care 13, 429 (1982): Staab W+, Stomatol DDR (German) 32, 700 Dermatitis (sic) (2001): Barnett L+, Ostomy Wound Manage 47(9), 47 (2001): Barrazza V, Contact Dermatitis 45(1), 42 (1998): Ebo DG+, J Allergy Clin Immunol 101, 128

(1998): Thune P, Tidsskr Nor Laegeforen (Norwegian) 18, 3295 (1995): Stingeni L+, Contact Dermatitis 33, 172 (1990): Reynolds NJ+, Contact Dermatitis 22, 103 (1988): Bergqvist-Karlsson A, Contact Dermatitis 18, 84 (1987): Osmundsen PE+, Ugeskr Laeger (Danish) 149, 3048 (1985): Lasthein Andersen B+, Contact Dermatitis 13, 307 (5.4%) (1983): Shoji A, Contact Dermatitis 9, 156 (1982): Osmundsen PE, Contact Dermatitis 8, 81 (1981): Roberts DL+, Contact Dermatitis 7, 326 (1972): Ljunggren B+, Acta Derm Venereol (Stockh) 52, 308 (1972): Neering H+, Ned Tijdschr Geneeskd (Dutch) 116, 1742 Facial edema (<1%) Fixed eruption (1991): Moghadam BK+, Oral Surg Oral Med Oral Pathol 71, 431 Photosensitivity (1971): Wahlberg JE+, Dermatologica 143, 376 Rash (sic) (2001): Garvey LH+, Acta Anaesthesiol Scand 45(10), 1290 (4 cases) Urticaria (1998): Stables GI+, Br J Urol 82, 756 (1990): Wong WK+, Contact Dermatitis 22, 52 (contact) (1989): Fisher AA, Cutis 43, 17 (1988): Bergqvist-Karlsson A, Contact Dermatitis 18, 84

Other Anaphylactoid reactions

(2001): Garvey LH+, Acta Anaesthesiol Scand 45(10), 1204 (4 cases) (2001): Knight BA+, Intern Med J 31(7), 436 (2001): Lockhart AS+, Br J Anaesth 87(6), 940 (2001): Stephens R+, Br J Anaesth 87(2), 306 (with sulfadiazine) (2000): Pham NH+, Clin Exp Allergy 30, 1001 (1999): Autegarden JE+, Contact Dermatitis 40, 215 (1999): Snellman E+, J Am Acad Dermatol 40, 771 (1998): Ebo DG+, J Allergy Clin Immunol 101, 128 (1998): Nikaido S+, Masui (Japanese) 47, 330 (1998): Olivieri J+, Schweiz Med Wochenschr 128, 1508 (1998): Terazawa E+, Anesthesiology 89, 1296 (1998): Thune P, Tidsskr Nor Laegeforen (Norwegian) 118, 3295 (1997): Chisholm DG+, BMJ 315, 785 (1997): Fujita S+, Masui (Japanese) 46, 1118 (2 cases) (1996): Torricelli R, Clin Exp Allergy 26, 112 (1995): Parker F+, Anaesth Intensive Care 23, 126 (1994): de Groot AC+, Ned Tijdschr Geneeskd (Dutch) 138, 1342 (1994): Okuda T+, Masui (Japanese) 43, 1352 (1994): Russ BR+, Anaesth Intensive Care 22, 611

(1994): Visser LE+, Ned Tijdschr Geneeskd (Dutch) 138, 778 (1992): Evans RJ, BMJ 304, 686 (1992): Harukuni I+, Masui (Japanese) 41, 455 (1992): Peutrell JM, Anaesthesia 47, 1013 (1990): Wong WK+, Contact Dermatitis 22, 52 Dysgeusia (>10%) (1978): Schaupp H+, HNO (German) 26, 335 Gingivitis (1984): Asikainen S+, J Clin Periodontol 11, 87 (1982): Ainamo J+, J Clin Periodontol 9, 337 Glossitis (1-10%) Hypersensitivity (2001): Lauerma AL, Contact Dermatitis 44(1), 59 (1998): Burlington B, Ostomy Wound Manage 44, 84 (1994): Aalto-Korte K+, Duodecim (Finnish) 110, 2013 (1989): Okano M+, Arch Dermatol 125, 50 (6 cases) (1988): Bergqvist-Karlsson A, Contact Dermatitis 18, 84 (1986): Ohtoshi T+, Clin Allergy 16, 155 (1986): Yaacob H+, J Oral Med 41, 145 (1971): Wahlberg JE+, Dermatological 143, 376 Oral mucosal reaction (1982): Skoglund LA+, Int J Oral Surg 11, 380 (3 cases) Stomatitis (1-10%) Tongue irritation (1-10%) Tongue pigmentation (>10%) Tooth pigmentation (2002): Moshrefi A, J West Soc Periodontol Periodontal Abstr 50(1), 5

Trade name: Trancopal (Sanofi-Synthelabo) Indications: Anxiety Category: Antianxiety Half-life: 24 hours

Reactions

Skin Ankle edema

Edema Erythema multiforme

Exanthems (1989): Alanko K+, Acta Derm Venereol (Stockh) 69, 223 (1964): Welsh AL, Med Clin North Am 48, 459 Fixed eruption (1998): Leal G, Fortaleza, Brazil (from Internet) (observation) (1998): Lee AY, Contact Dermatitis 38(5), 258 (1998): Mahboob A+, Int J Dermatol 37, 833 (1995): Rademacher D+, Contact Dermatitis 32, 117 (1992): el-Sayed F+, Ann Dermatol Venereol (French) 119, 671 (1991): Lee AY+, Drug Intell Clin Pharm 25, 604 (1989): Alanko K+, Acta Derm Venereol (Stockh) 69, 223 (1988): McFadden N, Dermatologica 176, 106 (1985): Kauppinen K+, Br J Dermatol 112, 575 (1985): Verbov J, Dermatologica 171, 60 (with acetaminophen) (1983): Mohamed KN+, Int J Dermatol 22, 548 (1974): Kuokkanen K, Int J Dermatol 13, 4 (1964): Welsh AL, Med Clin North Am 48, 459 Flushing Pruritus (1964): Welsh AL, Med Clin North Am 48, 459 Rash (sic) (1991): Lee AY+, Drug Intell Clin Pharm 25, 604 (passim) Stevens-Johnson syndrome (1995): Roujeau JC+, N Engl J Med 333, 1600 (1995): Wolkenstein P+, Drug Saf 13, 56 Toxic epidermal necrolysis (1998): von Boxberg C+, Dtsch Med Wochenschr (German) 123, 866 (fatal) (1996): Blum L+, J Am Acad Dermatol 34, 1088 (1995): Roujeau JC+, N Engl J Med 333, 1600 (1993): Correia O+, Dermatology 186, 32 (1992): Saiag P+, J Am Acad Dermatol 26, 567 (1991): Rosenthal E+, Presse Med (French) 20, 1459 (1987): Guillaume JC+, Arch Dermatol 123, 1166 (1983): Tagami H+, Arch Dermatol 119, 910 Urticaria

Other Acute intermittent porphyria

Death Dysgeusia (1976): Rollin H, Laryngol Rhinol Otol (Stuttgart) (German) 55, 873 Xerostomia (1964): Welsh AL, Med Clin North Am 48, 459