ABSTRACT
Trade names: Poladex; Polaramine (Schering); Tanafed (First Horizon) Other common trade names: Delamin; Polaramin; Polaronil; Polazit; Trenolone Indications: Allergic rhinitis, urticaria Category: Antihistamine H1-blocker Half-life: 20-24 hours Clinically important, potentially hazardous interactions with: barbiturates, chloral
hydrate, ethchlorvynol, glutethimide, phenothiazines, zolpidem
Reactions
Skin Angioedema (<1%)
Chills Dermatitis (1989): Cusano F+, Contact Dermatitis 21, 340 Diaphoresis Edema (<1%) Photosensitivity (<1%) Rash (sic) (<1%) Urticaria
Other Anaphylactoid reactions
Headache Myalgia (<1%) Paresthesias (<1%) Xerostomia (1-10%)
Trade name: Precedex (Abbott) Indications: Sedation for intensive care unit intubation Category: Alpha-adrenoceptor blocker; Sedative Half-life: 2 hours
Reactions
Skin Diaphoresis (<1%)
Infections (sic) (2%) Photopsia (<1%) Xerosis
Other Pain (3%)
Sialopenia (1990): Aantaa RE+, Anesth Analg 70, 407
Trade names: Adderall (Shire); Dexedrine (GSK) Other common trade names: Dexamphetamine; Dexamphetamini; Dextrostat;
Ferndex; Oxydess Indications: Narcolepsy, attention deficit disorder (ADD) Category: Amphetamine; Central nervous system stimulant Half-life: 10-12 hours Clinically important, potentially hazardous interactions with: fluoxetine,
fluvoxamine, MAO inhibitors, paroxetine, phenelzine, sertraline, tranylcypromine
Reactions
Skin Chills
Diaphoresis (1-10%) Rash (sic) (<1%) Toxic epidermal necrolysis (1975): Giallorenzi AF+, Oral Surg Oral Med Oral Pathol 40, 611 Urticaria (<1%)
Other Dysgeusia
Headache Rhabdomyolysis (2000): Richards JR, J Emerg Med 19(1), 51 (1999): Hedetoft C+, Ugeskr Laeger 161(50), 6907
(1998): Robertsen A+, Tidsskr Nor Laegeforen 118(28), 4340 (1996): Hofland E+, Ned Tijdschr Geneeskd 140(12), 681 (1996): Roebroek RM+, Ned Tijdschr Geneeskd 140(29), 1519 (1996): Roebroek RM+, Ned Tijdschr Geneeskd 140(4), 205 (1996): Sultana SR+, J R Coll Surg Edinb 41(6), 419 (1992): Kao CH+, Clin Nucl Med 17(2), 101 (1990): Yamazaki F+, Nippon Naika Gakkai 79(1), 100 (1977): Kendrick WC+, Ann Intern Med 86(4), 381 (5 cases) Xerostomia (1-10%)
Trade names: Benylin (Warner Lambert); Cheracol-D; Pertussin; Robitussin (Wyeth); Sucrets; Suppress; Trocal; Vicks Formula 44 (Procter & Gamble)
Other common trade names: Balminil; Delsym; Koffex; Triaminic DM Indications: Nonproductive cough Category: Antitussive (nonnarcotic) Half-life: N/A Clinically important, potentially hazardous interactions with: linezolid, phenelzine,
sibutramine, tranylcypromine, valdecoxib
Reactions
Skin Bullous eruption
(1999): Sahn EE, Dermatology Times April, 5 (infant with urticaria pigmentosa) (1996): Cook J+, Pediatr Dermatol 13, 410 (infant with urticaria pigmentosa) Fixed eruption (1991): Smoller BR+, J Cutan Pathol 18, 13 (1990): Stubb S+, Arch Dermatol 126, 970
Other Anaphylactoid reactions
(1998): Knowles SR+, J Allergy Clin Immunol 102, 316 Headache
