ABSTRACT
Tenuate Retard; Tepanil Indications: Weight reduction Category: Anorexiant; CNS stimulant Half-life: 4-6 hours Clinically important, potentially hazardous interactions with: fluoxetine,
fluvoxamine, MAO inhibitors, paroxetine, phenelzine, sertraline, tranylcypromine
Reactions
Skin Diaphoresis (<1%)
Ecchymoses Erythema (<1%) Erythema multiforme (1997): Thaler D, Monona, WI (from internet) (observation) Exanthems (<1%) Flushing (<1%) Pruritus (<1%) Purpura (<1%) Rash (sic) Scleroderma (1991): Bourgeois P+, Baillieres Clin Rheumatol 5, 13 (1990): Aeschlimann A+, Scand J Rheumatol 19, 87 Systemic sclerosis (1984): TomlinsonJW+, J Rheumatol 11, 254 Urticaria
Hair Hair-alopecia (<1%)
Other Dysgeusia
Gynecomastia Headache Myalgia (<1%)
Tremor Xerostomia
Synonyms: DES; stilbestrol Trade names: Diethylstilbestrol; Stilphostrol Other common trade names: Diethyl Stilbestrol; Distilbene; Honvol; Stilboestrol Indications: Metastatic prostate carcinoma, progressive breast cancer Category: Antineoplastic; Estrogen; Osteoporosis prophylactic Half-life: 2-3 days
Reactions
Skin Acanthosis nigricans
(1974): Banuchi SR+, Arch Dermatol 109, 544 (1971): Curth HO, Birth Defects 7, 31 Acne Angioedema (1942): Saphir WS+, JAMA 119, 557 Bullous eruption (1971): Kuchera LK, JAMA 218, 562 Chloasma (<1%) Edema Erythema multiforme Erythema nodosum Exanthems (1984): Lee M+, J Urol 131,767 Exfoliatlve dermatitis (1942): Kasselberg LA, JAMA 120, 117 Flushing (1981): Ingle JN+, N Engl J Med 304, 16 (3%) Hyperkeratosis of nipples (1980): Mold DE+, Cutis 26, 95 Lupus erythematosus (1989): Collins D, J Rheumatol 16, 408 Melasma (<1%) Peripheral edema (>10%) Pruritus (1971): Kuchera LK, JAMA 218, 562
Purpura (1984): Lee M+, J Urol 131, 767 Rash (sic) (<1%) Urticaria (1989): Collins D, J Rheumatol 16, 408 (1984): Lee M+, J Urol 131, 767
Hair Hair-alopecia
Hair-hirsutism (1982): Peress MR+, Am J Obstet Gynecol 144, 135
Other Gynecomastia (>10%)
Mastodynia (>10%) Periarteritis nodosa (1967): Keyloun V+, Vasc Dis 4, 21 Porphyria cutanea tarda (1989): Coulson IH+, Br J Urol 63, 648 (1978): Weimar VM+, J Urol 120, 643 (1972): Reginster JP, Arch Belg Dermatol Syphiligr (French) 28, 179 (1970): Domonkos AN, Arch Dermatol 102, 229 (1970): Roenigk HH+, Arch Dermatol 102, 260 (1969): Degos R+, Ann Dermatol Syphiligr Paris (French) 96, 5 (1967): Thivolet J+, Dermatologica (French) 135, 455 (1967): Vail JT, JAMA 201, 671 (1966): Copeman PW+, BMJ 5485, 461 (1966): Levere RD, Blood 28, 569 (1965): Becker FT, Arch Dermatol 92, 252 (1964): Theologides H+, Metabolism 13, 391 (1963): Hurley HJ, Arch Dermatol 88, 233 (1963): Walshe M, Br J Dermatol 75, 298 Vaginal candidiasis
Trade name: Dolobid (Merck) Other common trade names: Ansal; Apo-Diflunisal; Diflonid; Diflusal; Dolobis;
Donobid; Fluniget; Flustar; Nu-Diflunisal Indications: Rheumatoid and osteoarthritis Category: Nonsteroidal anti-inflammatory (NSAID) analgesic Half-life: 8-12 hours
Clinically important, potentially hazardous interactions with: indomethacin
Reactions
Skin Adverse effects (sic)
(1985): Lee P+, J Rheumatol 12, 544 (1983): McQueen EG, N Z Med J 96, 95 Angioedema (<1%) Bullous eruption (1989): Street ML+, J Am Acad Dermatol 20, 850 Diaphoresis (<1%) (1986): Muncie HL+, J Fam Pract 23, 125 (1979): Papatheodossiou N, Curr Med Res Opinion 6, 154 Edema (<1%) Erythema multiforme (<1%) (1986): Grom JA+, Hosp Formul Manage 21, 353 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (5%) (1985): O’Brien WM+, J Rheumatol 12, 13 (1982): Dubois A+, Presse Med (French) 11, 606 (1978): Hunter JA+, BMJ 2, 1088 Erythroderma (1989): Street ML+, J Am Acad Dermatol 20, 850 (1980): Chan LK+, BMJ 280, 84 Exanthems (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
180 (passim) (1988): Cook DJ+, Can Med Assoc J 138, 1029 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (5%) (1985): Bocanegra TS+, Curr Res Med Opin 9, 568 (1.7%) Exfoliative dermatitis (<1%) (1985): Bigby M+, J Am Acad Dermatol 12, 866 Fixed eruption (1998): Mahboob A+, Int J Dermatol 37, 833 (1991): Roetzheim RG+, J Am Acad Dermatol 24, 1021 (nonpigmenting) Flushing (<1%) Lichenoid eruption (1989): Street ML+, J Am Acad Dermatol 20, 850 Peripheral edema Photosensitivity (<1%) (1989): Street ML+, J Am Acad Dermatol 20, 850 Pruritus (1-10%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
ISO(passim)
(1986): Hurme M+, Int J Clin Pharmacol Res 6, 53 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (5%) Purpura Rash (sic) (3-9%) (1987): Masden JJ+, Curr Ther Res 42, 319 (1986): Bennett RM, Clin Ther 9, 27 (1986): Turner RA+, Clin Ther 9, 37 Stevens-Johnson syndrome (<1%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
180 (passim) (1986): Grom JA+, Hosp Formul Manage 21, 353 (1986): Szczeklik A, Drugs 32(Suppl 4), 148 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1982): Dubois A+, Presse Med (French) 11, 606 (1979): Curr Probl 4, 2 (1978): Hunter JA+, BMJ 2, 1088 Toxic epidermal necrolysis (<1%) (1990): Roujeau JC+, Arch Dermatol 126, 37 Urticaria (>1%) (1995): Arias J+, Ann Allergy Asthma Immunol 74, 160 (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
180 (passim) (1987): Morse DR+, Clin Ther 9, 500 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (5%) (1983): Griffin JP, Practitioner 227, 1283 (passim) (1980): Chan LK+, BMJ 280, 84 Vasculitis (<1%)
Hair Hair-alopecia
(1978): Bresnihan B+, Curr Med Res Opinion 5, 556
Nails Nails-onycholysis
Other Anaphylactoid reactions (<1%)
Aphthous stomatitis Headache Hypersensitivlty (<1%) Oral lichen planus (1983): Hamburger J+, BMJ 287, 1258 Oral ulceration Paresthesias (<1%) Pseudolymphoma (2001): Werth V, Dermatology Times 18
Pseudoporphyria (1987): Taylor BJ+, N Z Med J 100, 322 Stomatitis (<1%) Tinnitus Trembling (<1%) Xerostomia (1982): Ankri J+, Clin Ther 5, 85
Trade names: Lanoxicaps (GSK); Lanoxin (GSK) Other common trade names: Cardigox; Digacin; Digoxine; Eudigox; Lanicor;
Lenoxin; Novo-Digoxin Indications: Congestive heart failure, atrial fibrillation Category: Antiarrhythmic; Cardiac glycoside; Inotropic Half-life: 36-48 hours Clinically important, potentially hazardous interactions with: alprazolam,
amiodarone, amphotericin B, arbutamine, bendroflumethiazide, benzthiazide, bumetanide, chlorothiazide, chlorthalidone, cholestyramine, clarithromycin, cyclosporine, cyclothiazide, demeclocycline, devil’s claw, doxycycline, erythromycin, esomeprazole, ethacrynic acid, furosemide, hawthorn (fruit, leaf, flower extract), hydrochlorothiazide, hydroflumethiazide, indapamide, licorice, methyclothiazide, metolazone, minocycline, mistletoe, oxytetracycline, polythiazide, propafenone, propantheline, quinethazone, quinidine, rifampin, sarsaparilla, senna, Siberian ginseng, St John’s wort, teriparatide, tetracycline, thiazide diuretics, trichlormethiazide, verapamil
Reactions
Skin Angioedema
Bullous eruption (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
216 (passim) Diaphoresis (1980): Lofgren RP, N Engl J Med 302, 919 Exanthems (1.6%) (1994): Martin SJ+, JAMA 271, 1905 (generalized) (1994): Shelley WB+, Cutis 54, 76 (observation) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
216 (passim)
Pruritus (1994): Martin SJ+, JAMA 271, 1905 (generalized) Psoriasis (1981): David M+, J Am Acad Dermatol 5, 702 Purpura (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
216 (passim) Rash (sic) Urticaria (1994): Shelley WB+, Cutis 54, 76 (observation) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
216 (passim) Vasculitis (1972): Brauner GJ+, Cutis 10, 441
Hair Hair-alopecia
Nails Nails-loss (finger-and toenails)
Other Dyschromatopsia (green vision)
(2002): Lawrenson JG+, Br J Ophthalmol 86(11), 1259 Gynecomastia (2000): Hugues FC+, Ann Med Interne (Paris) (French) 151, 10 (passim) Headache Xanthopsia
Trade names: D.H.E. 45 (Novartis); Migranal (Xcel) Other common trade names: Dergiflux; Dihydergot; Ergont; Ergovasan; Ikaran;
Orstanorm; Seglor; Verladyn; Verteblan Indications: Prevention of vascular headaches Category: Ergot alkaloid Half-life: 1.3-3.9 hours Clinically important, potentially hazardous interactions with: almotriptan,
amprenavir, clarithromycin, delavirdine, efavirenz, erythromycin, indinavir, naratriptan, nelfinavir, ritonavir, rizatriptan, saquinavir, sibutramine, sumatriptan, troleandomycin, zolmitriptan
Reactions
Skin Edema (>10%)
Pruritus
Other Dysgeusia
Headache Injection-site reactions (sic) Myalgia Paresthesias (>10%) Xerostomia (>10%)
Trade names: DHT (Roxane); Hytakerol (Sanofi-Synthelabo) Other common trade names: AT 10; Dihydral; Dygratyl Indications: Hypocalcemia associated with hypoparathyroidism Category: Fat-soluble vitamin Half-life: N/A
Reactions
Skin Calcification
(1985): Michel B+, Schweiz Med Wochenschr (German) 115, 418 Exanthems Livedo reticularis (1985): Michel B+, Schweiz Med Wochenschr (German) 115, 418 Pruritus (1-10%)
Other Dysgeusia (metallic taste)
Myalgia Ulcerative necrosis (1985): Michel B+, Schweiz Med Wochenschr (German) 115, 418 Xerostomia
